6MSL

Integrin AlphaVBeta3 ectodomain bound to EETI-II 2.5D

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Integrin alpha-V	polymer	967	106970.6	1	UniProt (P06756) Pfam (PF01839) Pfam (PF08441) Pfam (PF20805) Pfam (PF20806)	Homo sapiens (Human)	Vitronectin receptor,Vitronectin receptor subunit alpha
2	B (B)	Integrin beta-3	polymer	695	76848.6	1	UniProt (P05106) Pfam (PF07974) Pfam (PF07965) Pfam (PF17205) Pfam (PF00362) Pfam (PF18372)	Homo sapiens (Human)	Platelet membrane glycoprotein IIIa,GPIIIa
3	C (C)	Cystine Knot Protein 2.5D	polymer	32	3235.6	1	Pfam (PF00299) UniProt (by SIFTS) (P12071)	Ecballium elaterium
4	D, G (D, G)	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	2	In PDB GlyTouCan (G81315DD)
5	E, H, I, J, K (E, H, I, J, K)	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	5	In PDB GlyTouCan (G42666HT)
6	F (F)	alpha-D-mannopyranose-(1-4)-beta-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1073.0	1	In PDB GlyTouCan (G93290PO)
7	L (L)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	1	In PDB GlyTouCan (G15407YE)
8	M, N, T, U (A, B)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	4	Chemie (NAG)
9	O, P, Q, R, S... (A, B)	MANGANESE (II) ION	non-polymer		54.9	8	Chemie (MN)
10	Y, Z (A, B)	water	water		18.0	4	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	187054.7
Branched	Number of molecules	9
	Total formula weight	5278.9
Non-Polymers*	Number of molecules	12
	Total formula weight	1324.3
All*	Total formula weight	193658.0

*Water molecules are not included.