6UJC

Integrin alpha-v beta-8 in complex with the Fabs C6-RGD3 and 11D12v2

Summary for 6UJC

Entry DOI	10.2210/pdb6ujc/pdb
EMDB information	20794 20795 20796 20797 20798 20799 20800 20801 20802 21125
Descriptor	Integrin alpha-V, Integrin beta-8, C6-RGD3 heavy chain Fab, ... (9 entities in total)
Functional Keywords	glycoprotein, adhesion, signaling, signaling protein-immune system complex, signaling protein/immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	244922.50
Authors	Campbell, M.G.,Cormier, A.,Cheng, Y.,Nishimura, S.L. (deposition date: 2019-10-02, release date: 2020-02-05, Last modification date: 2020-07-29)
Primary citation	Campbell, M.G.,Cormier, A.,Ito, S.,Seed, R.I.,Bondesson, A.J.,Lou, J.,Marks, J.D.,Baron, J.L.,Cheng, Y.,Nishimura, S.L. Cryo-EM Reveals Integrin-Mediated TGF-beta Activation without Release from Latent TGF-beta. Cell, 180:490-, 2020 Cited by PubMed: 31955848 DOI: 10.1016/j.cell.2019.12.030 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.56 Å)

Structure validation