7NXD

Cryo-EM structure of human integrin alpha5beta1 in the half-bent conformation

Summary for 7NXD

• Entry DOI: 10.2210/pdb7nxd/pdb
• Related: 3fcs 3vi3 4wk0 7NWL
• EMDB information: 12637
• Descriptor: Integrin alpha-5, Integrin beta-1, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• Functional Keywords: integrin, cell adhesion, plasma membrane protein, a5b1, alpha5beta1, focal adhesion, half-bent conformation
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 204742.42

Authors

Schumacher, S.,Dedden, D.,Vazquez Nunez, R.,Matoba, K.,Takagi, J.,Biertumpfel, C.,Mizuno, N. (deposition date: 2021-03-18, release date: 2021-08-25)

• Primary citation: Schumacher, S.,Dedden, D.,Nunez, R.V.,Matoba, K.,Takagi, J.,Biertumpfel, C.,Mizuno, N.; Structural insights into integrin alpha 5 beta 1 opening by fibronectin ligand.; Sci Adv, 7:-, 2021; PubMed: 33962943; DOI: 10.1126/sciadv.abe9716

Experimental method

ELECTRON MICROSCOPY (4.6 Å)