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7NXD

Cryo-EM structure of human integrin alpha5beta1 in the half-bent conformation

Functional Information from GO Data
ChainGOidnamespacecontents
A0001525biological_processangiogenesis
A0001618molecular_functionvirus receptor activity
A0001726cellular_componentruffle
A0005154molecular_functionepidermal growth factor receptor binding
A0005161molecular_functionplatelet-derived growth factor receptor binding
A0005178molecular_functionintegrin binding
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005783cellular_componentendoplasmic reticulum
A0005794cellular_componentGolgi apparatus
A0005886cellular_componentplasma membrane
A0005911cellular_componentcell-cell junction
A0005925cellular_componentfocal adhesion
A0007044biological_processcell-substrate junction assembly
A0007155biological_processcell adhesion
A0007157biological_processheterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
A0007159biological_processleukocyte cell-cell adhesion
A0007160biological_processcell-matrix adhesion
A0007229biological_processintegrin-mediated signaling pathway
A0007565biological_processfemale pregnancy
A0007613biological_processmemory
A0008305cellular_componentintegrin complex
A0009897cellular_componentexternal side of plasma membrane
A0009986cellular_componentcell surface
A0010811biological_processpositive regulation of cell-substrate adhesion
A0023035biological_processCD40 signaling pathway
A0030335biological_processpositive regulation of cell migration
A0030949biological_processpositive regulation of vascular endothelial growth factor receptor signaling pathway
A0031410cellular_componentcytoplasmic vesicle
A0031589biological_processcell-substrate adhesion
A0032587cellular_componentruffle membrane
A0033627biological_processcell adhesion mediated by integrin
A0033631biological_processcell-cell adhesion mediated by integrin
A0034113biological_processheterotypic cell-cell adhesion
A0034674cellular_componentintegrin alpha5-beta1 complex
A0035313biological_processwound healing, spreading of epidermal cells
A0035987biological_processendodermal cell differentiation
A0043184molecular_functionvascular endothelial growth factor receptor 2 binding
A0045202cellular_componentsynapse
A0045211cellular_componentpostsynaptic membrane
A0045765biological_processregulation of angiogenesis
A0046718biological_processsymbiont entry into host cell
A0046872molecular_functionmetal ion binding
A0050731biological_processpositive regulation of peptidyl-tyrosine phosphorylation
A0050839molecular_functioncell adhesion molecule binding
A0070161cellular_componentanchoring junction
A0071062cellular_componentalphav-beta3 integrin-vitronectin complex
A0098609biological_processcell-cell adhesion
A0098978cellular_componentglutamatergic synapse
A1903672biological_processpositive regulation of sprouting angiogenesis
A2000811biological_processnegative regulation of anoikis
B0000082biological_processG1/S transition of mitotic cell cycle
B0000132biological_processestablishment of mitotic spindle orientation
B0000287molecular_functionmagnesium ion binding
B0001618molecular_functionvirus receptor activity
B0001701biological_processin utero embryonic development
B0001726cellular_componentruffle
B0001968molecular_functionfibronectin binding
B0002020molecular_functionprotease binding
B0002042biological_processcell migration involved in sprouting angiogenesis
B0002052biological_processpositive regulation of neuroblast proliferation
B0003779molecular_functionactin binding
B0005178molecular_functionintegrin binding
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005737cellular_componentcytoplasm
B0005768cellular_componentendosome
B0005886cellular_componentplasma membrane
B0005925cellular_componentfocal adhesion
B0006909biological_processphagocytosis
B0006968biological_processcellular defense response
B0007155biological_processcell adhesion
B0007156biological_processhomophilic cell adhesion via plasma membrane adhesion molecules
B0007159biological_processleukocyte cell-cell adhesion
B0007160biological_processcell-matrix adhesion
B0007161biological_processcalcium-independent cell-matrix adhesion
B0007179biological_processtransforming growth factor beta receptor signaling pathway
B0007229biological_processintegrin-mediated signaling pathway
B0007405biological_processneuroblast proliferation
B0007517biological_processmuscle organ development
B0007520biological_processmyoblast fusion
B0008283biological_processcell population proliferation
B0008305cellular_componentintegrin complex
B0008354biological_processgerm cell migration
B0008542biological_processvisual learning
B0009897cellular_componentexternal side of plasma membrane
B0009986cellular_componentcell surface
B0010008cellular_componentendosome membrane
B0010710biological_processregulation of collagen catabolic process
B0010763biological_processpositive regulation of fibroblast migration
B0014704cellular_componentintercalated disc
B0015026molecular_functioncoreceptor activity
B0016020cellular_componentmembrane
B0016477biological_processcell migration
B0019901molecular_functionprotein kinase binding
B0019960molecular_functionC-X3-C chemokine binding
B0021943biological_processformation of radial glial scaffolds
B0023035biological_processCD40 signaling pathway
B0030027cellular_componentlamellipodium
B0030030biological_processcell projection organization
B0030032biological_processlamellipodium assembly
B0030175cellular_componentfilopodium
B0030182biological_processneuron differentiation
B0030183biological_processB cell differentiation
B0030198biological_processextracellular matrix organization
B0030335biological_processpositive regulation of cell migration
B0031175biological_processneuron projection development
B0031410cellular_componentcytoplasmic vesicle
B0031589biological_processcell-substrate adhesion
B0031594cellular_componentneuromuscular junction
B0031623biological_processreceptor internalization
B0032154cellular_componentcleavage furrow
B0032587cellular_componentruffle membrane
B0033627biological_processcell adhesion mediated by integrin
B0033631biological_processcell-cell adhesion mediated by integrin
B0034113biological_processheterotypic cell-cell adhesion
B0034665cellular_componentintegrin alpha1-beta1 complex
B0034666cellular_componentintegrin alpha2-beta1 complex
B0034667cellular_componentintegrin alpha3-beta1 complex
B0034668cellular_componentintegrin alpha4-beta1 complex
B0034674cellular_componentintegrin alpha5-beta1 complex
B0034675cellular_componentintegrin alpha6-beta1 complex
B0034677cellular_componentintegrin alpha7-beta1 complex
B0034678cellular_componentintegrin alpha8-beta1 complex
B0034679cellular_componentintegrin alpha9-beta1 complex
B0034680cellular_componentintegrin alpha10-beta1 complex
B0034681cellular_componentintegrin alpha11-beta1 complex
B0034682cellular_componentintegrin alphav-beta1 complex
B0035024biological_processnegative regulation of Rho protein signal transduction
B0035313biological_processwound healing, spreading of epidermal cells
B0035633biological_processmaintenance of blood-brain barrier
B0035748cellular_componentmyelin sheath abaxonal region
B0042383cellular_componentsarcolemma
B0042470cellular_componentmelanosome
B0042995cellular_componentcell projection
B0043065biological_processpositive regulation of apoptotic process
B0043149biological_processstress fiber assembly
B0043197cellular_componentdendritic spine
B0043235cellular_componentreceptor complex
B0043236molecular_functionlaminin binding
B0043547biological_processpositive regulation of GTPase activity
B0044877molecular_functionprotein-containing complex binding
B0045121cellular_componentmembrane raft
B0045202cellular_componentsynapse
B0045214biological_processsarcomere organization
B0045296molecular_functioncadherin binding
B0045445biological_processmyoblast differentiation
B0045665biological_processnegative regulation of neuron differentiation
B0045743biological_processpositive regulation of fibroblast growth factor receptor signaling pathway
B0045766biological_processpositive regulation of angiogenesis
B0045906biological_processnegative regulation of vasoconstriction
B0046718biological_processsymbiont entry into host cell
B0046872molecular_functionmetal ion binding
B0046982molecular_functionprotein heterodimerization activity
B0048333biological_processmesodermal cell differentiation
B0048471cellular_componentperinuclear region of cytoplasm
B0048626biological_processmyoblast fate specification
B0048675biological_processaxon extension
B0048813biological_processdendrite morphogenesis
B0050804biological_processmodulation of chemical synaptic transmission
B0050839molecular_functioncell adhesion molecule binding
B0050901biological_processleukocyte tethering or rolling
B0051726biological_processregulation of cell cycle
B0051897biological_processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
B0051951biological_processpositive regulation of glutamate uptake involved in transmission of nerve impulse
B0055007biological_processcardiac muscle cell differentiation
B0055037cellular_componentrecycling endosome
B0060379biological_processcardiac muscle cell myoblast differentiation
B0060912biological_processcardiac cell fate specification
B0070062cellular_componentextracellular exosome
B0070161cellular_componentanchoring junction
B0071404biological_processcellular response to low-density lipoprotein particle stimulus
B0071711biological_processbasement membrane organization
B0090303biological_processpositive regulation of wound healing
B0097060cellular_componentsynaptic membrane
B0097386cellular_componentglial cell projection
B0098609biological_processcell-cell adhesion
B0098639molecular_functioncollagen binding involved in cell-matrix adhesion
B0098640molecular_functionintegrin binding involved in cell-matrix adhesion
B0098685cellular_componentSchaffer collateral - CA1 synapse
B0098978cellular_componentglutamatergic synapse
B0150003biological_processregulation of spontaneous synaptic transmission
B0150053cellular_componentcerebellar climbing fiber to Purkinje cell synapse
B0150103biological_processreactive gliosis
B1900748biological_processpositive regulation of vascular endothelial growth factor signaling pathway
B1901979biological_processregulation of inward rectifier potassium channel activity
B1903078biological_processpositive regulation of protein localization to plasma membrane
B1905806biological_processregulation of synapse pruning
B1990782molecular_functionprotein tyrosine kinase binding
B2000811biological_processnegative regulation of anoikis
Functional Information from PROSITE/UniProt
site_idPS00022
Number of Residues12
DetailsEGF_1 EGF-like domain signature 1. CrCneGrvGRhC
ChainResidueDetails
BCYS469-CYS480
BCYS559-CYS570

site_idPS00242
Number of Residues8
DetailsINTEGRIN_ALPHA Integrins alpha chain signature. YKlGFFkR
ChainResidueDetails
ATYR980-ARG987

site_idPS00243
Number of Residues14
DetailsINTEGRIN_BETA Integrins beta chain cysteine-rich domain signature. CsNn..GeCvCgqCvC
ChainResidueDetails
BCYS505-CYS518
BCYS548-CYS561
BCYS587-CYS600

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues707
DetailsTOPO_DOM: Extracellular => ECO:0000255
ChainResidueDetails
BGLN1-ASP708

site_idSWS_FT_FI2
Number of Residues22
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
BILE709-TRP731

site_idSWS_FT_FI3
Number of Residues46
DetailsTOPO_DOM: Cytoplasmic => ECO:0000255
ChainResidueDetails
BLYS732-LYS778

site_idSWS_FT_FI4
Number of Residues2
DetailsBINDING: in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0000269|PubMed:33962943, ECO:0007744|PDB:3VI3, ECO:0007744|PDB:3VI4, ECO:0007744|PDB:7NXD
ChainResidueDetails
BSER132
BGLU229

site_idSWS_FT_FI5
Number of Residues1
DetailsBINDING: in MIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI4
ChainResidueDetails
BSER134
AASP301
AASP360
AASP362
AASP364
ATYR366
AASP368
AASP424
AASP426
AASN428
ATYR430
ASER241
AASP432
AASP243
ATHR245
AASP247
AASP293
AASN295
AASP297
ALEU299

site_idSWS_FT_FI6
Number of Residues3
DetailsBINDING: in ADMIDAS binding site => ECO:0000269|PubMed:22451694, ECO:0000269|PubMed:33962943, ECO:0007744|PDB:3VI3, ECO:0007744|PDB:7NXD
ChainResidueDetails
BASP137
BASP138
BALA342

site_idSWS_FT_FI7
Number of Residues1
DetailsBINDING: in LIMBS binding site => ECO:0000269|PubMed:22451694, ECO:0007744|PDB:3VI3, ECO:0007744|PDB:3VI4
ChainResidueDetails
BGLU169
AASN141
AASN275
AASN568

site_idSWS_FT_FI8
Number of Residues3
DetailsBINDING: in LIMBS binding site => ECO:0000269|PubMed:22451694, ECO:0000269|PubMed:33962943, ECO:0007744|PDB:3VI3, ECO:0007744|PDB:3VI4, ECO:0007744|PDB:7NXD
ChainResidueDetails
BASN224
BASP226
BPRO228

site_idSWS_FT_FI9
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332
ChainResidueDetails
BTHR757

site_idSWS_FT_FI10
Number of Residues1
DetailsMOD_RES: Phosphotyrosine => ECO:0007744|PubMed:23186163
ChainResidueDetails
BTYR763
AASN552
AASN671
AASN683
AASN827

site_idSWS_FT_FI11
Number of Residues1
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
BSER765

site_idSWS_FT_FI12
Number of Residues1
DetailsMOD_RES: Phosphothreonine => ECO:0007744|PubMed:24275569
ChainResidueDetails
BTHR769

site_idSWS_FT_FI13
Number of Residues1
DetailsMOD_RES: N6-acetyllysine; alternate => ECO:0007744|PubMed:19608861
ChainResidueDetails
BLYS774

site_idSWS_FT_FI14
Number of Residues5
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BASN30
BASN74
BASN77
BASN500
BASN564

site_idSWS_FT_FI15
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218
ChainResidueDetails
BASN192

site_idSWS_FT_FI16
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:22451694, ECO:0000269|PubMed:33962943, ECO:0007744|PDB:3VI3, ECO:0007744|PDB:3VI4, ECO:0007744|PDB:7NWL, ECO:0007744|PDB:7NXD
ChainResidueDetails
BASN249

site_idSWS_FT_FI17
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:33962943, ECO:0007744|PDB:7NWL, ECO:0007744|PDB:7NXD
ChainResidueDetails
BASN343
BASN397

site_idSWS_FT_FI18
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19349973, ECO:0000269|PubMed:22451694, ECO:0000269|PubMed:33962943, ECO:0007744|PDB:3VI3, ECO:0007744|PDB:3VI4, ECO:0007744|PDB:7NWL, ECO:0007744|PDB:7NXD
ChainResidueDetails
BASN386

site_idSWS_FT_FI19
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:33962943, ECO:0007744|PDB:7NXD
ChainResidueDetails
BASN461

site_idSWS_FT_FI20
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218, ECO:0000269|PubMed:33962943, ECO:0007744|PDB:7NWL, ECO:0007744|PDB:7NXD
ChainResidueDetails
BASN649

site_idSWS_FT_FI21
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternate => ECO:0007744|PubMed:25114211
ChainResidueDetails
BLYS774

222926

PDB entries from 2024-07-24

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