7NXD

Cryo-EM structure of human integrin alpha5beta1 in the half-bent conformation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Integrin alpha-5	polymer	1008	110111.6	1	UniProt (P08648) Pfam (PF01839) Pfam (PF08441) Pfam (PF20805) Pfam (PF20806) In PDB	Homo sapiens (Human)	CD49 antigen-like family member E,Fibronectin receptor subunit alpha,Integrin alpha-F,VLA-5
2	B	Integrin beta-1	polymer	778	86338.6	1	UniProt (P05556) Pfam (PF07965) Pfam (PF08725) Pfam (PF17205) Pfam (PF00362) Pfam (PF18372) Pfam (PF07974) In PDB	Homo sapiens (Human)	Fibronectin receptor subunit beta,Glycoprotein IIa,GPIIA,VLA-4 subunit beta
3	C, E, M, O, P	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	5
4	D	alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		748.7	1
5	F, H, I, J, K...	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		424.4	7	In PDB GlyTouCan (G42666HT)
6	G	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		1114.0	1
7	A, B	CALCIUM ION	non-polymer		40.1	7	Chemie (CA)
8	A	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
9	B	MAGNESIUM ION	non-polymer		24.3	1	Chemie (MG)

Sequence modifications

B: 1 - 778 (UniProt: P05556)

PDB	External Database	Details
His 92	Thr 112	conflict
Thr 195	Ser 215	conflict

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	196450.1
Branched	Number of molecules	14
	Total formula weight	7766.2
Non-Polymers*	Number of molecules	9
	Total formula weight	526.1
All*	Total formula weight	204742.4

*Water molecules are not included.