7NXD
Cryo-EM structure of human integrin alpha5beta1 in the half-bent conformation
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Integrin alpha-5 | polymer | 1008 | 110111.6 | 1 | UniProt (P08648) Pfam (PF01839) Pfam (PF08441) Pfam (PF20805) Pfam (PF20806) | Homo sapiens (Human) | CD49 antigen-like family member E,Fibronectin receptor subunit alpha,Integrin alpha-F,VLA-5 |
| 2 | B (B) | Integrin beta-1 | polymer | 778 | 86338.6 | 1 | UniProt (P05556) Pfam (PF07965) Pfam (PF08725) Pfam (PF17205) Pfam (PF00362) Pfam (PF18372) Pfam (PF07974) | Homo sapiens (Human) | Fibronectin receptor subunit beta,Glycoprotein IIa,GPIIA,VLA-4 subunit beta |
| 3 | C, E, M, O, P (C, E, M, O, P) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 5 | In PDB GlyTouCan (G15407YE) | |||
| 4 | D (D) | alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G81315DD) | |||
| 5 | F, H, I, J, K... (F, H, I, J, K...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 7 | In PDB GlyTouCan (G42666HT) | |||
| 6 | G (G) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1114.0 | 1 | In PDB GlyTouCan (G64481DJ) | |||
| 7 | Q, R, S, T, U... (A, B) | CALCIUM ION | non-polymer | 40.1 | 7 | Chemie (CA) | |||
| 8 | V (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 1 | Chemie (NAG) | |||
| 9 | W (B) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) |
Sequence modifications
B: 1 - 778 (UniProt: P05556)
| PDB | External Database | Details |
|---|---|---|
| His 92 | Thr 112 | conflict |
| Thr 195 | Ser 215 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 196450.1 | |
| Branched | Number of molecules | 14 |
| Total formula weight | 7766.2 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 526.1 | |
| All* | Total formula weight | 204742.4 |
