7NWL
Cryo-EM structure of human integrin alpha5beta1 (open form) in complex with fibronectin and TS2/16 Fv-clasp
Summary for 7NWL
Entry DOI | 10.2210/pdb7nwl/pdb |
Related | 1fnf 3vi3 4wk0 5cxc 7NXD |
EMDB information | 12634 |
Descriptor | Integrin alpha-5, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MANGANESE (II) ION, ... (11 entities in total) |
Functional Keywords | integrin, fibronectin, ts2/16, cell adhesion, plasma membrane protein, a5b1, alpha5beta1, focal adhesion, open conformation |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 5 |
Total formula weight | 280943.50 |
Authors | Schumacher, S.,Dedden, D.,Vazquez Nunez, R.,Matoba, K.,Takagi, J.,Biertumpfel, C.,Mizuno, N. (deposition date: 2021-03-17, release date: 2021-06-02) |
Primary citation | Schumacher, S.,Dedden, D.,Nunez, R.V.,Matoba, K.,Takagi, J.,Biertumpfel, C.,Mizuno, N. Structural insights into integrin alpha 5 beta 1 opening by fibronectin ligand. Sci Adv, 7:-, 2021 Cited by PubMed: 33962943DOI: 10.1126/sciadv.abe9716 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.1 Å) |
Structure validation
Download full validation report![Download](/newweb/media/icons/dl.png)
![Download](/newweb/media/icons/dl.png)