7NWL
Cryo-EM structure of human integrin alpha5beta1 (open form) in complex with fibronectin and TS2/16 Fv-clasp
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Integrin alpha-5 | polymer | 1008 | 110111.6 | 1 | UniProt (P08648) Pfam (PF01839) Pfam (PF08441) Pfam (PF20805) Pfam (PF20806) | Homo sapiens (Human) | CD49 antigen-like family member E,Fibronectin receptor subunit alpha,Integrin alpha-F,VLA-5 |
| 2 | B (B) | Integrin beta-1 | polymer | 778 | 86338.6 | 1 | UniProt (P05556) Pfam (PF07965) Pfam (PF08725) Pfam (PF17205) Pfam (PF00362) Pfam (PF18372) Pfam (PF07974) | Homo sapiens (Human) | Fibronectin receptor subunit beta,Glycoprotein IIa,GPIIA,VLA-4 subunit beta |
| 3 | C (C) | Isoform 1 of Fibronectin | polymer | 368 | 39981.2 | 1 | UniProt (P02751) Pfam (PF00041) | Homo sapiens (Human) | FN,Cold-insoluble globulin,CIG |
| 4 | D (D) | TS2/16 VH(S112C)-SARAH Chimera | polymer | 172 | 19464.0 | 1 | Mus musculus | ||
| 5 | E (E) | TS2/16 VL-SARAH(S37C) Chimera | polymer | 164 | 18270.7 | 1 | Mus musculus | ||
| 6 | F, G, K, M (F, G, K, M) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 4 | In PDB GlyTouCan (G15407YE) | |||
| 7 | H, L, O (H, L, O) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 3 | In PDB GlyTouCan (G42666HT) | |||
| 8 | I (I) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
| 9 | J (J) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1114.0 | 1 | In PDB GlyTouCan (G64481DJ) | |||
| 10 | N (N) | alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 748.7 | 1 | In PDB GlyTouCan (G22573RC) | |||
| 11 | P, Q, R, S, T... (A, B) | MANGANESE (II) ION | non-polymer | 54.9 | 7 | Chemie (MN) |
Sequence modifications
B: 1 - 778 (UniProt: P05556)
| PDB | External Database | Details |
|---|---|---|
| His 92 | Thr 112 | conflict |
| Thr 195 | Ser 215 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 274166.0 | |
| Branched | Number of molecules | 10 |
| Total formula weight | 6392.9 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 384.6 | |
| All* | Total formula weight | 280943.5 |
