6NAJ
Integrin AlphaVBeta3 ectodomain bound to Hr10 variant of the 10th domain of Fibronectin.
Summary for 6NAJ
| Entry DOI | 10.2210/pdb6naj/pdb |
| Related | 3IJE 4MMZ |
| Descriptor | Integrin alpha-V, Integrin beta-3, Fibronectin, HR10 variant, ... (9 entities in total) |
| Functional Keywords | hybrid domain, psi, egf repeats, beta tail, calf, thigh, beta propeller, rgd motif, fibronectin, vitronectin, cell adhesion |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 3 |
| Total formula weight | 197249.80 |
| Authors | van Agthoven, J.,Arnaout, M.A. (deposition date: 2018-12-05, release date: 2019-12-11, Last modification date: 2023-11-15) |
| Primary citation | Adair, B.D.,Alonso, J.L.,van Agthoven, J.,Hayes, V.,Ahn, H.S.,Yu, I.S.,Lin, S.W.,Xiong, J.P.,Poncz, M.,Arnaout, M.A. Structure-guided design of pure orthosteric inhibitors of alpha IIb beta 3 that prevent thrombosis but preserve hemostasis. Nat Commun, 11:398-398, 2020 Cited by PubMed: 31964886DOI: 10.1038/s41467-019-13928-2 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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