6NAJ
Integrin AlphaVBeta3 ectodomain bound to Hr10 variant of the 10th domain of Fibronectin.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Integrin alpha-V | polymer | 954 | 105541.8 | 1 | UniProt (P06756) Pfam (PF01839) Pfam (PF08441) Pfam (PF20805) Pfam (PF20806) | Homo sapiens (human) | Vitronectin receptor,Vitronectin receptor subunit alpha |
| 2 | B (B) | Integrin beta-3 | polymer | 690 | 76310.9 | 1 | UniProt (P05106) Pfam (PF07974) Pfam (PF07965) Pfam (PF17205) Pfam (PF00362) Pfam (PF18372) | Homo sapiens (human) | Platelet membrane glycoprotein IIIa,GPIIIa |
| 3 | C (C) | Fibronectin, HR10 variant | polymer | 90 | 9627.6 | 1 | UniProt (P02751) Pfam (PF00041) | Homo sapiens (human) | FN,Cold-insoluble globulin,CIG |
| 4 | D, F, G, H, J (D, F, G, H, J) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 5 | In PDB GlyTouCan (G42666HT) | |||
| 5 | E (E) | alpha-D-mannopyranose-(1-4)-beta-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 1 | In PDB GlyTouCan (G93290PO) | |||
| 6 | I (I) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 1 | In PDB GlyTouCan (G15407YE) | |||
| 7 | K, L, M, N, O... (A, B) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 7 | Chemie (NAG) | |||
| 8 | P, Q, R, S, T... (A, B) | MANGANESE (II) ION | non-polymer | 54.9 | 8 | Chemie (MN) | |||
| 9 | AA, BA, Z (B, C, A) | water | water | 18.0 | 6 | Chemie (HOH) |
Sequence modifications
C: 1417 - 1506 (UniProt: P02751)
| PDB | External Database | Details |
|---|---|---|
| Pro 1492 | Gly 1614 | conflict |
| - | Ser 1618 | deletion |
| Trp 1496 | Pro 1619 | conflict |
| Asn 1497 | Ala 1620 | conflict |
| Glu 1498 | Ser 1621 | conflict |
| Gly 1499 | Ser 1622 | conflict |
| Gly 1500 | Lys 1623 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 191480.3 | |
| Branched | Number of molecules | 7 |
| Total formula weight | 3781.5 | |
| Non-Polymers* | Number of molecules | 15 |
| Total formula weight | 1988.0 | |
| All* | Total formula weight | 197249.8 |
