1B47
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STRUCTURE OF THE N-TERMINAL DOMAIN OF CBL IN COMPLEX WITH ITS BINDING SITE IN ZAP-70
Descriptor:CBL, CALCIUM ION
Authors:Meng, W., Sawasdikosol, S., Burakoff, S.J., Eck, M.J.
Deposit date:1999-01-06
Release date:1999-04-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase.
Nature, 398, 1999
1FBV
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STRUCTURE OF A CBL-UBCH7 COMPLEX: RING DOMAIN FUNCTION IN UBIQUITIN-PROTEIN LIGASES
Descriptor:SIGNAL TRANSDUCTION PROTEIN CBL, ZAP-70 PEPTIDE, UBIQUITIN-CONJUGATING ENZYME E12-18 KDA UBCH7, ...
Authors:Zheng, N., Wang, P., Jeffrey, P.D., Pavletich, N.P.
Deposit date:2000-07-17
Release date:2000-08-30
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases.
Cell(Cambridge,Mass.), 102, 2000
1YVH
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CRYSTAL STRUCTURE OF THE C-CBL TKB DOMAIN IN COMPLEX WITH THE APS PTYR-618 PHOSPHOPEPTIDE
Descriptor:CBL E3 ubiquitin protein ligase, 13-mer fragment of SH2 and PH domain-containing adapter protein APS, MAGNESIUM ION
Authors:Hu, J., Hubbard, S.R.
Deposit date:2005-02-15
Release date:2005-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural Characterization of a Novel Cbl Phosphotyrosine Recognition Motif in the APS Family of Adapter Proteins
J.Biol.Chem., 280, 2005
2CBL
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N-TERMINAL DOMAIN OF CBL IN COMPLEX WITH ITS BINDING SITE ON ZAP-70
Descriptor:PROTO-ONCOGENE CBL, ZAP-70, CALCIUM ION
Authors:Meng, W., Sawasdikosol, S., Burakoff, S.J., Eck, M.J.
Deposit date:1998-08-28
Release date:1999-05-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of the amino-terminal domain of Cbl complexed to its binding site on ZAP-70 kinase.
Nature, 398, 1999
2Y1M
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STRUCTURE OF NATIVE C-CBL
Descriptor:E3 UBIQUITIN-PROTEIN LIGASE, ZINC ION, CALCIUM ION
Authors:Dou, H., Sibbet, G.J., Huang, D.T.
Deposit date:2010-12-08
Release date:2012-01-18
Last modified:2012-02-15
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl.
Nat.Struct.Mol.Biol., 19, 2012
2Y1N
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STRUCTURE OF C-CBL-ZAP-70 PEPTIDE COMPLEX
Descriptor:E3 UBIQUITIN-PROTEIN LIGASE, TYROSINE-PROTEIN KINASE ZAP-70 ZAP-70,70 KDA ZETA-ASSOCIATED PROTEIN, SYK-RELATED TYROSINE KINASE, ...
Authors:Dou, H., Sibbet, G.J., Huang, D.T.
Deposit date:2010-12-08
Release date:2012-01-18
Last modified:2012-02-15
Method:X-RAY DIFFRACTION (1.999 Å)
Cite:Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl.
Nat.Struct.Mol.Biol., 19, 2012
3BUM
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CRYSTAL STRUCTURE OF C-CBL-TKB DOMAIN COMPLEXED WITH ITS BINDING MOTIF IN SPROUTY2
Descriptor:Portein sprouty homolog 2, E3 ubiquitin-protein ligase CBL
Authors:Ng, C., Jackson, A.R., Buschdorf, P.J., Sun, Q., Guy, R.G., Sivaraman, J.
Deposit date:2008-01-03
Release date:2008-02-26
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
Embo J., 27, 2008
3BUN
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CRYSTAL STRUCTURE OF C-CBL-TKB DOMAIN COMPLEXED WITH ITS BINDING MOTIF IN SPROUTY4
Descriptor:13-meric peptide from Portein sprouty homolog 4, E3 ubiquitin-protein ligase CBL
Authors:Ng, C., Jackson, R.A., Buschdorf, J.P., Sun, Q., Guy, G.R., Sivaraman, J.
Deposit date:2008-01-03
Release date:2008-02-26
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
Embo J., 27, 2008
3BUO
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CRYSTAL STRUCTURE OF C-CBL-TKB DOMAIN COMPLEXED WITH ITS BINDING MOTIF IN EGF RECEPTOR'
Descriptor:13-meric peptide from Epidermal growth factor receptor, E3 ubiquitin-protein ligase CBL
Authors:Ng, C., Jackson, R.A., Buschdorf, J.P., Sun, Q., Guy, G.R., Sivaraman, J.
Deposit date:2008-01-03
Release date:2008-02-26
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
Embo J., 27, 2008
3BUW
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CRYSTAL STRUCTURE OF C-CBL-TKB DOMAIN COMPLEXED WITH ITS BINDING MOTIF IN SYK
Descriptor:13-meric peptide from Tyrosine-protein kinase SYK, E3 ubiquitin-protein ligase CBL
Authors:Ng, C., Jackson, R.A., Buschdorf, J.P., Sun, Q., Guy, G.R., Sivaraman, J.
Deposit date:2008-01-03
Release date:2008-02-26
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
Embo J., 27, 2008
3BUX
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CRYSTAL STRUCTURE OF C-CBL-TKB DOMAIN COMPLEXED WITH ITS BINDING MOTIF IN C-MET
Descriptor:13-meric peptide from Hepatocyte growth factor receptor, E3 ubiquitin-protein ligase CBL
Authors:Ng, C., Jackson, R.A., Buschdorf, J.P., Sun, Q., Guy, G.R., Sivaraman, J.
Deposit date:2008-01-03
Release date:2008-02-26
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates
Embo J., 27, 2008
3OB1
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CRYSTAL STRUCTURE OF C-CBL TKB DOMAIN IN COMPLEX WITH DOUBLE PHOSPHORYLATED SPRY2 PEPTIDE
Descriptor:12-meric peptide from Protein sprouty homolog 2, E3 ubiquitin-protein ligase CBL
Authors:Sun, Q., Sivaraman, J.
Deposit date:2010-08-06
Release date:2010-08-18
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Additional serine/threonine phosphorylation reduces binding affinity but preserves interface topography of substrate proteins to the c-Cbl TKB domain
Plos One, 5, 2010
3OB2
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CRYSTAL STRUCTURE OF C-CBL TKB DOMAIN IN COMPLEX WITH DOUBLE PHOSPHORYLATED EGFR PEPTIDE
Descriptor:12-meric peptide from Epidermal growth factor receptor, E3 ubiquitin-protein ligase CBL
Authors:Sun, Q., Sivaraman, J.
Deposit date:2010-08-06
Release date:2010-08-18
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Additional serine/threonine phosphorylation reduces binding affinity but preserves interface topography of substrate proteins to the c-Cbl TKB domain
Plos One, 5, 2010
3OP0
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CRYSTAL STRUCTURE OF CBL-C (CBL-3) TKB DOMAIN IN COMPLEX WITH EGFR PY1069 PEPTIDE
Descriptor:Signal transduction protein CBL-C, Epidermal growth factor receptor, SODIUM ION, ...
Authors:Chaikuad, A., Guo, K., Cooper, C.D.O., Ayinampudi, V., Krojer, T., Ugochukwu, E., Muniz, J.R.C., Vollmar, M., Canning, P., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2010-08-31
Release date:2010-10-20
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Crystal structure of Cbl-c (Cbl-3) TKB domain in complex with EGFR pY1069 peptide
To be Published
3PFV
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CRYSTAL STRUCTURE OF CBL-B TKB DOMAIN IN COMPLEX WITH EGFR PY1069 PEPTIDE
Descriptor:E3 ubiquitin-protein ligase CBL-B, 11-meric peptide from Epidermal growth factor receptor, SODIUM ION, ...
Authors:Chaikuad, A., Guo, K., Cooper, C.D.O., Ayinampudi, V., Krojer, T., Muniz, J.R.C., Vollmar, M., Canning, P., Gileadi, O., von Delft, F., Arrowsmith, C.H., Weigelt, J., Edwards, A.M., Bountra, C., Bullock, A., Structural Genomics Consortium (SGC)
Deposit date:2010-10-29
Release date:2010-12-08
Last modified:2014-04-02
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Crystal structure of Cbl-b TKB domain in complex with EGFR pY1069 peptide
To be Published
3PLF
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REVERSE BINDING MODE OF METRD PEPTIDE COMPLEXED WITH C-CBL TKB DOMAIN
Descriptor:MetRD peptide, E3 ubiquitin-protein ligase CBL, CALCIUM ION, ...
Authors:Sun, Q., Sivaraman, J.
Deposit date:2010-11-15
Release date:2010-12-01
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:An adjacent arginine, and the phosphorylated tyrosine in the c-Met receptor target sequence, dictates the orientation of c-Cbl binding
Febs Lett., 585, 2011
3VGO
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CRYSTAL STRUCTURE OF THE N-TERMINAL FRAGMENT OF CBL-B
Descriptor:E3 ubiquitin-protein ligase CBL-B
Authors:Kobashigawa, Y., Noda, N.N., Inagaki, F.
Deposit date:2011-08-18
Release date:2011-12-14
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Autoinhibition and phosphorylation-induced activation mechanisms of human cancer and autoimmune disease-related E3 protein Cbl-b
Proc.Natl.Acad.Sci.USA, 108, 2011
3VRN
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CRYSTAL STRUCTURE OF THE TYROSINE KINASE BINDING DOMAIN OF CBL-C
Descriptor:Signal transduction protein CBL-C, CALCIUM ION
Authors:Takeshita, K., Tezuka, T., Isozaki, Y., Yamashita, E., Suzuki, M., Yamanashi, Y., Yamamoto, T., Nakagawa, A.
Deposit date:2012-04-13
Release date:2013-03-06
Method:X-RAY DIFFRACTION (1.64 Å)
Cite:Structural flexibility regulates phosphopeptide-binding activity of the tyrosine kinase binding domain of Cbl-c
J.Biochem., 152, 2012
3VRO
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CRYSTAL STRUCTURE OF THE TYROSINE KINASE BINDING DOMAIN OF CBL-C IN COMPLEX WITH PHOSPHO-SRC PEPTIDE
Descriptor:Signal transduction protein CBL-C, Proto-oncogene tyrosine-protein kinase Src, CALCIUM ION
Authors:Takeshita, K., Tezuka, T., Isozaki, Y., Yamashita, E., Suzuki, M., Yamanashi, Y., Yamamoto, T., Nakagawa, A.
Deposit date:2012-04-13
Release date:2013-03-06
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural flexibility regulates phosphopeptide-binding activity of the tyrosine kinase binding domain of Cbl-c.
J.Biochem., 152, 2012
3VRP
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CRYSTAL STRUCTURE OF THE TYROSINE KINASE BINDING DOMAIN OF CBL-C IN COMPLEX WITH PHOSPHO-EGFR PEPTIDE
Descriptor:Signal transduction protein CBL-C, Epidermal growth factor receptor, CALCIUM ION
Authors:Takeshita, K., Tezuka, T., Isozaki, Y., Yamashita, E., Suzuki, M., Yamanashi, Y., Yamamoto, T., Nakagawa, A.
Deposit date:2012-04-13
Release date:2013-03-06
Method:X-RAY DIFFRACTION (1.52 Å)
Cite:Structural flexibility regulates phosphopeptide-binding activity of the tyrosine kinase binding domain of Cbl-c.
J.Biochem., 152, 2012
3VRQ
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CRYSTAL STRUCTURE OF THE TYROSINE KINASE BINDING DOMAIN OF CBL-C (PL MUTANT)
Descriptor:Signal transduction protein CBL-C, CALCIUM ION
Authors:Takeshita, K., Tezuka, T., Isozaki, Y., Yamashita, E., Suzuki, M., Yamanashi, Y., Yamamoto, T., Nakagawa, A.
Deposit date:2012-04-13
Release date:2013-03-06
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Structural flexibility regulates phosphopeptide-binding activity of the tyrosine kinase binding domain of Cbl-c.
J.Biochem., 152, 2012
3VRR
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CRYSTAL STRUCTURE OF THE TYROSINE KINASE BINDING DOMAIN OF CBL-C (PL MUTANT) IN COMPLEX WITH PHOSPHO-EGFR PEPTIDE
Descriptor:Signal transduction protein CBL-C, Epidermal growth factor receptor, CALCIUM ION
Authors:Takeshita, K., Tezuka, T., Isozaki, Y., Yamashita, E., Suzuki, M., Yamanashi, Y., Yamamoto, T., Nakagawa, A.
Deposit date:2012-04-13
Release date:2013-03-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural flexibility regulates phosphopeptide-binding activity of the tyrosine kinase binding domain of Cbl-c.
J.Biochem., 152, 2012
3ZNI
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STRUCTURE OF PHOSPHOTYR363-CBL-B - UBCH5B-UB - ZAP-70 PEPTIDE COMPLEX
Descriptor:E3 UBIQUITIN-PROTEIN LIGASE CBL-B, TYROSINE-PROTEIN KINASE ZAP-70, UBIQUITIN-CONJUGATING ENZYME E2 D2, ...
Authors:Dou, H., Buetow, L., Sibbet, G.J., Cameron, K., Huang, D.T.
Deposit date:2013-02-14
Release date:2013-07-10
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.21 Å)
Cite:Essentiality of a Non-Ring Element in Priming Donor Ubiquitin for Catalysis by a Monomeric E3.
Nat.Struct.Mol.Biol., 20, 2013
4A4B
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STRUCTURE OF MODIFIED PHOSPHOTYR371-C-CBL-UBCH5B-ZAP-70 COMPLEX
Descriptor:E3 UBIQUITIN-PROTEIN LIGASE CBL, TYROSINE-PROTEIN KINASE ZAP-70, UBIQUITIN-CONJUGATING ENZYME E2 D2, ...
Authors:Dou, H., Buetow, L., Hock, A., Sibbet, G.J., Vousden, K.H., Huang, D.T.
Deposit date:2011-10-08
Release date:2012-01-25
Last modified:2012-02-29
Method:X-RAY DIFFRACTION (2.789 Å)
Cite:Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl
Nat.Struct.Mol.Biol., 19, 2012
4A4C
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STRUCTURE OF PHOSPHOTYR371-C-CBL-UBCH5B-ZAP-70 COMPLEX
Descriptor:E3 UBIQUITIN-PROTEIN LIGASE CBL, TYROSINE-PROTEIN KINASE ZAP-70, UBIQUITIN-CONJUGATING ENZYME E2 D2, ...
Authors:Dou, H., Buetow, L., Hock, A., Sibbet, G.J., Vousden, K.H., Huang, D.T.
Deposit date:2011-10-08
Release date:2012-01-25
Last modified:2012-02-29
Method:X-RAY DIFFRACTION (2.704 Å)
Cite:Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl
Nat.Struct.Mol.Biol., 19, 2012
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