4A4C

Structure of phosphoTyr371-c-Cbl-UbcH5B-ZAP-70 complex

Summary for 4A4C

Related1W4U 1M61 2ESK 1UR6 2ESO 1YVH 2ESP 2CBL 2ESQ 2C4O 1B47 1U59 1FBV 2CLW 4A4B 4A49 2Y1M 2Y1N
DescriptorE3 UBIQUITIN-PROTEIN LIGASE CBL, TYROSINE-PROTEIN KINASE ZAP-70, UBIQUITIN-CONJUGATING ENZYME E2 D2, ... (6 entities in total)
Functional Keywordsligase-transferase complex, ligase/transferase
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains3
Total molecular weight63423.2
Authors
Dou, H.,Buetow, L.,Hock, A.,Sibbet, G.J.,Vousden, K.H.,Huang, D.T. (deposition date: 2011-10-08, release date: 2012-01-25, Last modification date: 2019-04-03)
Primary citation
Dou, H.,Buetow, L.,Hock, A.,Sibbet, G.J.,Vousden, K.H.,Huang, D.T.
Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl
Nat.Struct.Mol.Biol., 19:184-, 2012
PubMed: 22266821 (PDB entries with the same primary citation)
DOI: 10.1038/NSMB.2231
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.704 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.266120 5.3% 3.5%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution