3BUM
Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Sprouty2
Summary for 3BUM
Entry DOI | 10.2210/pdb3bum/pdb |
Related | 3BUN 3BUO 3BUW 3BUX |
Descriptor | Protein sprouty homolog 2, E3 ubiquitin-protein ligase CBL (3 entities in total) |
Functional Keywords | ligase, signal transduction, proto-oncogene, complex, cytoplasm, developmental protein, membrane, microtubule, polymorphism, calcium, metal-binding, phosphoprotein, sh2 domain, ubl conjugation pathway, zinc, zinc-finger |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 39766.65 |
Authors | Ng, C.,Jackson, A.R.,Buschdorf, P.J.,Sun, Q.,Guy, R.G.,Sivaraman, J. (deposition date: 2008-01-03, release date: 2008-02-26, Last modification date: 2023-11-15) |
Primary citation | Ng, C.,Jackson, R.A.,Buschdorf, J.P.,Sun, Q.,Guy, G.R.,Sivaraman, J. Structural basis for a novel intrapeptidyl H-bond and reverse binding of c-Cbl-TKB domain substrates Embo J., 27:804-816, 2008 Cited by PubMed: 18273061DOI: 10.1038/emboj.2008.18 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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