Structure of native c-Cbl

Summary for 2Y1M

Related2CBL 2Y1N 4A4B 4A4C 4A49 1B47 1FBV 1YVH
DescriptorE3 UBIQUITIN-PROTEIN LIGASE, ZINC ION, CALCIUM ION, ... (4 entities in total)
Functional Keywordsligase, ubiquitin ring e3 ligase
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCytoplasm P22681
Total number of polymer chains6
Total molecular weight270597.55
Dou, H.,Sibbet, G.J.,Huang, D.T. (deposition date: 2010-12-08, release date: 2012-01-18, Last modification date: 2012-02-15)
Primary citation
Dou, H.,Buetow, L.,Hock, A.,Sibbet, G.J.,Vousden, K.H.,Huang, D.T.
Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl.
Nat.Struct.Mol.Biol., 19:184-, 2012
PubMed: 22266821 (PDB entries with the same primary citation)
DOI: 10.1038/NSMB.2231
MImport into Mendeley
Experimental method
NMR Information

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.257240.4%8.4%4.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution