1YVH

Crystal Structure of the c-Cbl TKB Domain in Complex with the APS pTyr-618 Phosphopeptide

Summary for 1YVH

• Entry DOI: 10.2210/pdb1yvh/pdb
• Descriptor: CBL E3 ubiquitin protein ligase, 13-mer fragment of SH2 and PH domain-containing adapter protein APS, MAGNESIUM ION, ... (4 entities in total)
• Functional Keywords: x-ray crystallography; phosphotyrosine; adapter protein, ligase, signaling protein, immune system
• Biological source: Homo sapiens (human); More
• Cellular location: Cytoplasm: P22681 Q9Z200
• Total number of polymer chains: 2
• Total formula weight: 39859.06

Authors

Hu, J.,Hubbard, S.R. (deposition date: 2005-02-15, release date: 2005-03-08, Last modification date: 2023-11-15)

• Primary citation: Hu, J.,Hubbard, S.R.; Structural Characterization of a Novel Cbl Phosphotyrosine Recognition Motif in the APS Family of Adapter Proteins; J.Biol.Chem., 280:18943-18949, 2005; PubMed: 15737992; DOI: 10.1074/jbc.M414157200

Experimental method

X-RAY DIFFRACTION (2.05 Å)