1YVH
Crystal Structure of the c-Cbl TKB Domain in Complex with the APS pTyr-618 Phosphopeptide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | CBL E3 ubiquitin protein ligase | polymer | 329 | 38192.1 | 1 | UniProt (P22681) Pfam (PF02262) Pfam (PF02761) Pfam (PF02762) | Homo sapiens (human) | Signal transduction protein CBL; Proto-oncogene c-CBL; Casitas B-lineage lymphoma proto- oncogene; RING finger protein 55 |
| 2 | B (B) | 13-mer fragment of SH2 and PH domain-containing adapter protein APS | polymer | 13 | 1642.7 | 1 | UniProt (Q9Z200) | APS adapter protein | |
| 3 | C (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 188 | Chemie (HOH) |
Sequence modifications
A: 23 - 351 (UniProt: P22681)
B: 1 - 13 (UniProt: Q9Z200)
| PDB | External Database | Details |
|---|---|---|
| Ser 24 | Gly 24 | cloning artifact |
| PDB | External Database | Details |
|---|---|---|
| Ptr 10 | Tyr 618 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 39834.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 24.3 | |
| All* | Total formula weight | 39859.1 |
