Structure of phosphoTyr371-c-Cbl-UbcH5B complex

Summary for 4A49

Related2CBL 2Y1N 1W4U 4A4B 2ESQ 2C4O 4A4C 2ESK 1UR6 2Y1M 1B47 1FBV 2ESO 1YVH 2ESP 2CLW
DescriptorE3 ubiquitin-protein ligase CBL, Ubiquitin-conjugating enzyme E2 D2, ZINC ION, ... (5 entities in total)
Functional Keywordsligase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total molecular weight26433.76
Dou, H.,Buetow, L.,Hock, A.,Sibbet, G.J.,Vousden, K.H.,Huang, D.T. (deposition date: 2011-10-07, release date: 2012-01-25, Last modification date: 2018-11-21)
Primary citation
Dou, H.,Buetow, L.,Hock, A.,Sibbet, G.J.,Vousden, K.H.,Huang, D.T.
Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl.
Nat. Struct. Mol. Biol., 19:184-192, 2012
PubMed: 22266821 (PDB entries with the same primary citation)
DOI: 10.1038/nsmb.2231
MImport into Mendeley
Experimental method
NMR Information

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers 0.19950 3.0% 1.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution