4A49

Structure of phosphoTyr371-c-Cbl-UbcH5B complex

Summary for 4A49

Entry DOI	10.2210/pdb4a49/pdb
Related	1B47 1FBV 1UR6 1W4U 1YVH 2C4O 2CBL 2CLW 2ESK 2ESO 2ESP 2ESQ 2Y1M 2Y1N 4A4B 4A4C
Descriptor	E3 ubiquitin-protein ligase CBL, Ubiquitin-conjugating enzyme E2 D2, ZINC ION, ... (5 entities in total)
Functional Keywords	ligase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	26433.76
Authors	Dou, H.,Buetow, L.,Hock, A.,Sibbet, G.J.,Vousden, K.H.,Huang, D.T. (deposition date: 2011-10-07, release date: 2012-01-25, Last modification date: 2023-12-20)
Primary citation	Dou, H.,Buetow, L.,Hock, A.,Sibbet, G.J.,Vousden, K.H.,Huang, D.T. Structural basis for autoinhibition and phosphorylation-dependent activation of c-Cbl. Nat. Struct. Mol. Biol., 19:184-192, 2012 Cited by PubMed: 22266821 DOI: 10.1038/nsmb.2231 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.214 Å)

Structure validation