4A49
Structure of phosphoTyr371-c-Cbl-UbcH5B complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | E3 ubiquitin-protein ligase CBL | polymer | 84 | 9508.6 | 1 | UniProt (P22681) Pfam (PF00097) | Homo sapiens (Human) | Casitas B-lineage lymphoma proto-oncogene,Proto-oncogene c-Cbl,RING finger protein 55,RING-type E3 ubiquitin transferase CBL,Signal transduction protein CBL |
| 2 | B (B) | Ubiquitin-conjugating enzyme E2 D2 | polymer | 147 | 16755.2 | 1 | UniProt (P62837) Pfam (PF00179) | Homo sapiens (Human) | (E3-independent) E2 ubiquitin-conjugating enzyme D2,E2 ubiquitin-conjugating enzyme D2,Ubiquitin carrier protein D2,Ubiquitin-conjugating enzyme E2(17)KB 2,Ubiquitin-conjugating enzyme E2-17 kDa 2,Ubiquitin-protein ligase D2,p53-regulated ubiquitin-conjugating enzyme 1 |
| 3 | C, D (A) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 4 | E (B) | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) | |||
| 5 | F, G (A, B) | water | water | 18.0 | 132 | Chemie (HOH) |
Sequence modifications
A: 354 - 435 (UniProt: P22681)
| PDB | External Database | Details |
|---|---|---|
| Gly 352 | - | expression tag |
| Ser 353 | - | expression tag |
| Phe 368 | Tyr 368 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 26263.8 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 169.9 | |
| All* | Total formula weight | 26433.8 |
