2Y1N

Structure of c-Cbl-ZAP-70 peptide complex

Summary for 2Y1N

Related2CBL 4A4B 4A4C 1M61 4A49 2Y1M 1B47 1U59 1FBV 1YVH
DescriptorE3 UBIQUITIN-PROTEIN LIGASE, TYROSINE-PROTEIN KINASE ZAP-70 ZAP-70,70 KDA ZETA-ASSOCIATED PROTEIN, SYK-RELATED TYROSINE KINASE, ZINC ION, ... (5 entities in total)
Functional Keywordsligase-transferase complex, ubiquitin ring e3 ligase, ligase/transferase
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationCytoplasm P22681 P43403
Total number of polymer chains4
Total molecular weight92887.73
Authors
Dou, H.,Sibbet, G.J.,Huang, D.T. (deposition date: 2010-12-08, release date: 2012-01-18, Last modification date: 2012-02-15)
Primary citation
Dou, H.,Buetow, L.,Hock, A.,Sibbet, G.J.,Vousden, K.H.,Huang, D.T.
Structural Basis for Autoinhibition and Phosphorylation-Dependent Activation of C-Cbl.
Nat.Struct.Mol.Biol., 19:184-, 2012
PubMed: 22266821 (PDB entries with the same primary citation)
DOI: 10.1038/NSMB.2231
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.999 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.1781203.2%2.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2y1n
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Molmil generated image of 2y1n
rotated about x axis by 90°
Molmil generated image of 2y1n
rotated about y axis by 90°

More Biological unit images

Molmil generated image of 2y1n
no rotation
Molmil generated image of 2y1n
rotated about x axis by 90°
Molmil generated image of 2y1n
rotated about y axis by 90°
(*)In the case of coarse surface representation, the asymmetric unit is shown as red ribbon representation.
Coordinate files for Biological unit (2y1n.pdb1.gz [68.94 KB])
Coordinate files for Biological unit (2y1n.pdb2.gz [68.98 KB])