2Y1N

Structure of c-Cbl-ZAP-70 peptide complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0001784	molecular_function	phosphotyrosine residue binding
A	0004842	molecular_function	ubiquitin-protein transferase activity
A	0005509	molecular_function	calcium ion binding
A	0007166	biological_process	cell surface receptor signaling pathway
A	0023051	biological_process	regulation of signaling
A	0046872	molecular_function	metal ion binding
C	0001784	molecular_function	phosphotyrosine residue binding
C	0004842	molecular_function	ubiquitin-protein transferase activity
C	0005509	molecular_function	calcium ion binding
C	0007166	biological_process	cell surface receptor signaling pathway
C	0023051	biological_process	regulation of signaling
C	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1436

Chain	Residue
A	CYS381
A	CYS384
A	CYS401
A	CYS404

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 1437

Chain	Residue
A	CYS396
A	HIS398
A	CYS416
A	CYS419

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 1436

Chain	Residue
C	CYS384
C	CYS401
C	CYS404
C	CYS381

---

site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 1437

Chain	Residue
C	CYS396
C	HIS398
C	CYS416
C	CYS419

---

site_id	AC5
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 1438

Chain	Residue
A	ASP229
A	THR231
A	ASN233
A	TYR235
A	GLU240
A	HOH2071

---

site_id	AC6
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA C 1438

Chain	Residue
C	ASP229
C	THR231
C	ASN233
C	TYR235
C	GLU240
C	HOH2080

---

Functional Information from PROSITE/UniProt

site_id	PS00518
Number of Residues	10
Details	ZF_RING_1 Zinc finger RING-type signature. CgHlMCtsCL

Chain	Residue	Details
A	CYS396-LEU405

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	78
Details	Zinc finger: {"description":"RING-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00175","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	144
Details	Region: {"description":"EF-hand-like"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	204
Details	Region: {"description":"SH2-like"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PDB","id":"1B47","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CBL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine; by INSR","evidences":[{"source":"PubMed","id":"11997497","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"15144186","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"8943331","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---