2Y1M
Structure of native c-Cbl
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0001784 | molecular_function | phosphotyrosine residue binding |
| A | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| A | 0005509 | molecular_function | calcium ion binding |
| A | 0007166 | biological_process | cell surface receptor signaling pathway |
| A | 0023051 | biological_process | regulation of signaling |
| A | 0046872 | molecular_function | metal ion binding |
| B | 0001784 | molecular_function | phosphotyrosine residue binding |
| B | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| B | 0005509 | molecular_function | calcium ion binding |
| B | 0007166 | biological_process | cell surface receptor signaling pathway |
| B | 0023051 | biological_process | regulation of signaling |
| B | 0046872 | molecular_function | metal ion binding |
| C | 0001784 | molecular_function | phosphotyrosine residue binding |
| C | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| C | 0005509 | molecular_function | calcium ion binding |
| C | 0007166 | biological_process | cell surface receptor signaling pathway |
| C | 0023051 | biological_process | regulation of signaling |
| C | 0046872 | molecular_function | metal ion binding |
| D | 0001784 | molecular_function | phosphotyrosine residue binding |
| D | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| D | 0005509 | molecular_function | calcium ion binding |
| D | 0007166 | biological_process | cell surface receptor signaling pathway |
| D | 0023051 | biological_process | regulation of signaling |
| D | 0046872 | molecular_function | metal ion binding |
| E | 0001784 | molecular_function | phosphotyrosine residue binding |
| E | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| E | 0005509 | molecular_function | calcium ion binding |
| E | 0007166 | biological_process | cell surface receptor signaling pathway |
| E | 0023051 | biological_process | regulation of signaling |
| E | 0046872 | molecular_function | metal ion binding |
| F | 0001784 | molecular_function | phosphotyrosine residue binding |
| F | 0004842 | molecular_function | ubiquitin-protein transferase activity |
| F | 0005509 | molecular_function | calcium ion binding |
| F | 0007166 | biological_process | cell surface receptor signaling pathway |
| F | 0023051 | biological_process | regulation of signaling |
| F | 0046872 | molecular_function | metal ion binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1436 |
| Chain | Residue |
| A | CYS381 |
| A | CYS384 |
| A | CYS401 |
| A | CYS404 |
| site_id | AC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 1437 |
| Chain | Residue |
| A | CYS396 |
| A | HIS398 |
| A | CYS416 |
| A | CYS419 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 1436 |
| Chain | Residue |
| B | CYS384 |
| B | CYS401 |
| B | CYS404 |
| B | CYS381 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 1437 |
| Chain | Residue |
| B | CYS396 |
| B | HIS398 |
| B | CYS416 |
| B | CYS419 |
| site_id | AC5 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 1436 |
| Chain | Residue |
| C | CYS381 |
| C | CYS384 |
| C | CYS401 |
| C | CYS404 |
| site_id | AC6 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN C 1437 |
| Chain | Residue |
| C | CYS396 |
| C | HIS398 |
| C | CYS416 |
| C | CYS419 |
| site_id | AC7 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 1436 |
| Chain | Residue |
| D | CYS381 |
| D | CYS384 |
| D | CYS401 |
| D | CYS404 |
| site_id | AC8 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN D 1437 |
| Chain | Residue |
| D | CYS396 |
| D | HIS398 |
| D | CYS416 |
| D | CYS419 |
| site_id | AC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN E 1436 |
| Chain | Residue |
| E | CYS381 |
| E | ILE383 |
| E | CYS384 |
| E | CYS401 |
| E | CYS404 |
| site_id | BC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN E 1437 |
| Chain | Residue |
| E | CYS396 |
| E | HIS398 |
| E | CYS416 |
| E | CYS419 |
| site_id | BC2 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN F 1436 |
| Chain | Residue |
| F | CYS381 |
| F | CYS384 |
| F | CYS401 |
| F | CYS404 |
| site_id | BC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN F 1437 |
| Chain | Residue |
| F | CYS396 |
| F | HIS398 |
| F | CYS416 |
| F | CYS419 |
| site_id | BC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE CA B 1438 |
| Chain | Residue |
| B | ASP229 |
| B | THR231 |
| B | ASN233 |
| B | TYR235 |
| B | GLU240 |
| B | HOH2008 |
| site_id | BC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA D 1438 |
| Chain | Residue |
| D | ASP229 |
| D | THR231 |
| D | ASN233 |
| D | TYR235 |
| D | GLU240 |
| site_id | BC6 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA A 1438 |
| Chain | Residue |
| A | ASP229 |
| A | THR231 |
| A | ASN233 |
| A | TYR235 |
| A | GLU240 |
| site_id | BC7 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA C 1438 |
| Chain | Residue |
| C | ASP229 |
| C | THR231 |
| C | ASN233 |
| C | TYR235 |
| C | GLU240 |
| site_id | BC8 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA E 1438 |
| Chain | Residue |
| E | ASP229 |
| E | THR231 |
| E | ASN233 |
| E | TYR235 |
| E | GLU240 |
| site_id | BC9 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE CA F 1438 |
| Chain | Residue |
| F | ASP229 |
| F | THR231 |
| F | ASN233 |
| F | TYR235 |
| F | GLU240 |
Functional Information from PROSITE/UniProt
| site_id | PS00518 |
| Number of Residues | 10 |
| Details | ZF_RING_1 Zinc finger RING-type signature. CgHlMCtsCL |
| Chain | Residue | Details |
| A | CYS396-LEU405 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1824 |
| Details | Domain: {"description":"Cbl-PTB","evidences":[{"source":"PROSITE-ProRule","id":"PRU00839","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 234 |
| Details | Zinc finger: {"description":"RING-type","evidences":[{"source":"PROSITE-ProRule","id":"PRU00175","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 768 |
| Details | Region: {"description":"4H"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 432 |
| Details | Region: {"description":"EF-hand-like"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 612 |
| Details | Region: {"description":"SH2-like"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 30 |
| Details | Binding site: {"evidences":[{"source":"PDB","id":"1B47","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CBL","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"Phosphotyrosine; by INSR","evidences":[{"source":"PubMed","id":"11997497","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
