Structure of phosphoY371 c-CBL in complex with ZAP70-peptide and UbV.pCBL ubiquitin variant

Summary for 5O76

DescriptorE3 ubiquitin-protein ligase CBL, Tyrosine protein kinase ZAP70 peptide, UbV.pCBL ubiquitin variant, ... (6 entities in total)
Functional Keywordse3 ring ligase, ubiquitin variant, ligase
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm P22681
Total number of polymer chains6
Total molecular weight111580.85
Gabrielsen, M.,Buetow, L.,Huang, D.T. (deposition date: 2017-06-08, release date: 2017-11-01, Last modification date: 2018-01-24)
Primary citation
Gabrielsen, M.,Buetow, L.,Nakasone, M.A.,Ahmed, S.F.,Sibbet, G.J.,Smith, B.O.,Zhang, W.,Sidhu, S.S.,Huang, D.T.
A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants.
Mol. Cell, 68:456-470.e10, 2017
PubMed: 29053960 (PDB entries with the same primary citation)
DOI: 10.1016/j.molcel.2017.09.027
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.25910.4%3.4%5.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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