5O76

Structure of phosphoY371 c-CBL in complex with ZAP70-peptide and UbV.pCBL ubiquitin variant

Summary for 5O76

DescriptorE3 ubiquitin-protein ligase CBL, Tyrosine protein kinase ZAP70 peptide, UbV.pCBL ubiquitin variant, ... (6 entities in total)
Functional Keywordse3 ring ligase, ubiquitin variant, ligase
Biological sourceHomo sapiens (Human)
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Cellular locationCytoplasm P22681
Total number of polymer chains6
Total molecular weight111580.85
Authors
Gabrielsen, M.,Buetow, L.,Huang, D.T. (deposition date: 2017-06-08, release date: 2017-11-01, Last modification date: 2018-01-24)
Primary citation
Gabrielsen, M.,Buetow, L.,Nakasone, M.A.,Ahmed, S.F.,Sibbet, G.J.,Smith, B.O.,Zhang, W.,Sidhu, S.S.,Huang, D.T.
A General Strategy for Discovery of Inhibitors and Activators of RING and U-box E3 Ligases with Ubiquitin Variants.
Mol. Cell, 68:456-470.e10, 2017
PubMed: 29053960 (PDB entries with the same primary citation)
DOI: 10.1016/j.molcel.2017.09.027
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.473 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.25910.4%3.4%5.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution