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4VGC
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BU of 4vgc by Molmil
GAMMA-CHYMOTRYPSIN D-NAPHTHYL-1-ACETAMIDO BORONIC ACID INHIBITOR COMPLEX
Descriptor: D-1-NAPHTHYL-2-ACETAMIDO-ETHANE BORONIC ACID, GAMMA CHYMOTRYPSIN, SULFATE ION
Authors:Stoll, V.S, Eger, B.T, Hynes, R.C, Martichonok, V, Jones, J.B, Pai, E.F.
Deposit date:1997-05-01
Release date:1997-11-12
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Differences in binding modes of enantiomers of 1-acetamido boronic acid based protease inhibitors: crystal structures of gamma-chymotrypsin and subtilisin Carlsberg complexes.
Biochemistry, 37, 1998
6P0P
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BU of 6p0p by Molmil
Human beta-tryptase co-crystal structure with 5-{4-[3-(aminomethyl)phenyl]piperidine-1-carbonyl}-2-(3'-{4-[3-(aminomethyl)phenyl]piperidine-1-carbonyl}-[1,1'-biphenyl]-3-yl)-2-hydroxy-2H-1,3,2-benzodioxaborol-2-uide
Descriptor: (3'-{4-[3-(aminomethyl)phenyl]piperidine-1-carbonyl}[1,1'-biphenyl]-3-yl){4-[3-(aminomethyl)phenyl]piperidin-1-yl}[3,4-di(hydroxy-kappaO)phenyl]methanonato(2-)hydroxyborate(1-), 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, SULFATE ION, ...
Authors:Giardina, S.F, Pingle, M.R, Werner, D.S, Feinberg, P.B, Foreman, K.W, Bergstrom, D.E, Arnold, L.D, Barany, F.
Deposit date:2019-05-17
Release date:2020-03-25
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Novel, Self-Assembling Dimeric Inhibitors of Human beta Tryptase.
J.Med.Chem., 63, 2020
7AYS
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BU of 7ays by Molmil
Structure of bovine trypsin determined from single femtosecond snapshots per orientation at room temperature
Descriptor: BENZAMIDINE, CALCIUM ION, Cationic trypsin, ...
Authors:Jensen, M.
Deposit date:2020-11-13
Release date:2021-01-20
Last modified:2021-08-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:High-resolution macromolecular crystallography at the FemtoMAX beamline with time-over-threshold photon detection.
J.Synchrotron Radiat., 28, 2021
3KHV
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BU of 3khv by Molmil
Crystal Structures of Urokinase-type Plasminogen Activator in Complex with 4-(Aminomethyl) Benzoic Acid and 4-(Aminomethyl-phenyl)-methanol
Descriptor: SULFATE ION, TRIETHYLENE GLYCOL, Urokinase-type plasminogen activator, ...
Authors:Jiang, L.-G, Zhao, G.-X, Bian, X.-B, Yuan, C, Huang, Z.-X, Huang, M.-D.
Deposit date:2009-10-30
Release date:2009-12-01
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal Structures of Urokinase-type Plasminogen Activator in Complex with 4-(Aminomethyl) Benzoic Acid and 4-(Aminomethyl-phenyl)-methanol
CHIN.J.STRUCT.CHEM., 28, 2009
3KID
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BU of 3kid by Molmil
The Crystal Structures of 2-Aminobenzothiazole-based Inhibitors in Complexes with Urokinase-type Plasminogen Activator
Descriptor: Urokinase-type plasminogen activator, ethyl 2-amino-1,3-benzothiazole-6-carboxylate
Authors:Jiang, L.-G, Yu, H.Y, Yuan, C, Wang, J.D, Chen, L.Q, Meehan, E.J, Huang, Z.-X, Huang, M.-D.
Deposit date:2009-11-01
Release date:2009-12-01
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Crystal Structures of 2-Aminobenzothiazole-based Inhibitors in Complexes with Urokinase-type Plasminogen Activator
CHIN.J.STRUCT.CHEM., 28, 2009
3KGP
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BU of 3kgp by Molmil
Crystal Structures of Urokinase-type Plasminogen Activator in Complex with 4-(Aminomethyl) Benzoic Acid and 4-(Aminomethyl-phenyl)-methanol
Descriptor: 4-(aminomethyl)benzoic acid, SULFATE ION, Urokinase-type plasminogen activator
Authors:Jiang, L.-G, Zhao, G.-X, Bian, X.-B, Yuan, C, Huang, Z.-X, Huang, M.-D.
Deposit date:2009-10-29
Release date:2009-12-01
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal Structures of Urokinase-type Plasminogen Activator in Complex with 4-(Aminomethyl) Benzoic Acid and 4-(Aminomethyl-phenyl)-methanol
CHIN.J.STRUCT.CHEM., 28, 2009
6F5M
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BU of 6f5m by Molmil
Crystal structure of highly glycosylated human leukocyte elastase in complex with a thiazolidinedione inhibitor
Descriptor: 5-[[4-[[(2~{S})-4-methyl-1-oxidanylidene-1-[(2-propylphenyl)amino]pentan-2-yl]carbamoyl]phenyl]methyl]-2-oxidanylidene-1,3-thiazol-1-ium-4-olate, ACETATE ION, Neutrophil elastase, ...
Authors:Hochscherf, J, Pietsch, M, Tieu, W, Kuan, K, Hautmann, S, Abell, A, Guetschow, M, Niefind, K.
Deposit date:2017-12-01
Release date:2018-08-08
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structure of highly glycosylated human leukocyte elastase in complex with an S2' site binding inhibitor.
Acta Crystallogr F Struct Biol Commun, 74, 2018
5FAH
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BU of 5fah by Molmil
KALLIKREIN-7 IN COMPLEX WITH COMPOUND1
Descriptor: (2~{S})-~{N}2-[2-(4-methoxyphenyl)ethyl]-~{N}1-(naphthalen-1-ylmethyl)pyrrolidine-1,2-dicarboxamide, ACETATE ION, Kallikrein-7
Authors:Ostermann, N, Zink, F.
Deposit date:2015-12-11
Release date:2016-10-26
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Small-molecule factor D inhibitors targeting the alternative complement pathway.
Nat.Chem.Biol., 12, 2016
5FCK
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BU of 5fck by Molmil
COMPLEMENT FACTOR D IN COMPLEX WITH COMPOUND 5
Descriptor: 1-[2-[(1~{R},3~{S},5~{R})-3-[[(1~{R})-1-(3-chloranyl-2-fluoranyl-phenyl)ethyl]carbamoyl]-2-azabicyclo[3.1.0]hexan-2-yl]-2-oxidanylidene-ethyl]pyrazolo[3,4-c]pyridine-3-carboxamide, Complement factor D, SULFATE ION
Authors:Mac Sweeney, A.
Deposit date:2015-12-15
Release date:2016-10-26
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Small-molecule factor D inhibitors targeting the alternative complement pathway.
Nat.Chem.Biol., 12, 2016
6VLV
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BU of 6vlv by Molmil
Factor XIa in complex with compound 11
Descriptor: 1-carbamimidamido-4-chloro-N-[(2R)-3-methyl-1-(morpholin-4-yl)-1-oxobutan-2-yl]isoquinoline-7-sulfonamide, CITRATE ANION, Coagulation factor XIa light chain
Authors:Lesburg, C.A.
Deposit date:2020-01-27
Release date:2020-05-06
Last modified:2020-10-07
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Augmenting Hit Identification by Virtual Screening Techniques in Small Molecule Drug Discovery.
J.Chem.Inf.Model., 60, 2020
6VMK
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BU of 6vmk by Molmil
Crystal structure of human Complement Factor D with anti-Factor D Fab 20D12
Descriptor: Complement factor D, Fab Y49R heavy chain, Fab Y49R light chain, ...
Authors:Wu, P, Harris, S.F, Eigenbrot, C.
Deposit date:2020-01-28
Release date:2021-02-03
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Crystal structure of human Complement Factor D with anti-Factor D Fab 20D12
To Be Published
6VLU
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BU of 6vlu by Molmil
Factor XIa in complex with compound 7
Descriptor: CITRIC ACID, Coagulation factor XIa light chain, N-cyclohexyl-D-leucyl-N-[(1-aminoisoquinolin-6-yl)methyl]-4,4-difluoro-L-prolinamide
Authors:Lesburg, C.A, Fradera, X.
Deposit date:2020-01-27
Release date:2020-05-06
Last modified:2020-10-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Augmenting Hit Identification by Virtual Screening Techniques in Small Molecule Drug Discovery.
J.Chem.Inf.Model., 60, 2020
5FBI
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BU of 5fbi by Molmil
COMPLEMENT FACTOR D IN COMPLEX WITH COMPOUND 3b
Descriptor: 3-[(2-aminocarbonyl-1~{H}-indol-5-yl)oxymethyl]benzoic acid, Complement factor D, GLYCEROL
Authors:Ostermann, N, Zink, F.
Deposit date:2015-12-14
Release date:2016-10-26
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Small-molecule factor D inhibitors targeting the alternative complement pathway.
Nat.Chem.Biol., 12, 2016
5F8Z
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BU of 5f8z by Molmil
The crystal structure of human Plasma Kallikrein in complex with its peptide inhibitor pkalin-1
Descriptor: CYS-PRO-ALA-ARG-PHE-M70-ALA-LEU-PHE-CYS, Plasma kallikrein LIGHT CHAIN, SULFATE ION, ...
Authors:Xu, M, Jiang, L, Xu, P, Luo, Z, Andreasen, P, Huang, M.
Deposit date:2015-12-09
Release date:2016-12-14
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The crystal structure of human Plasma Kallikrein in complex with its peptide inhibitor pkalin-1
To Be Published
6VVU
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BU of 6vvu by Molmil
Anti-Tryptase fab E104.v1 bound to tryptase
Descriptor: CALCIUM ION, Fab E104.v1 heavy chain, Fab E104.v1 light chain, ...
Authors:Ultsch, M, Koerber, J.T.
Deposit date:2020-02-18
Release date:2020-12-30
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3 Å)
Cite:Bivalent antibody pliers inhibit beta-tryptase by an allosteric mechanism dependent on the IgG hinge.
Nat Commun, 11, 2020
8G1W
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BU of 8g1w by Molmil
Crystal Structure Matriptase (C731S) in Complex with Inhibitor VD4162B
Descriptor: CHLORIDE ION, Cyclic peptide inhibitor (ACE)Y(DTR)(NLE)(KCM), Cyclic peptide inhibitor (ACE)Y(DTR)(NLE)(THZ), ...
Authors:Lovell, S, Kashipathy, M.M, Battaile, K.P, Janetka, J.W.
Deposit date:2023-02-03
Release date:2024-02-07
Last modified:2024-04-10
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Mechanism-Based Macrocyclic Inhibitors of Serine Proteases.
J.Med.Chem., 67, 2024
5F8T
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BU of 5f8t by Molmil
The crystal structure of human Plasma Kallikrein in complex with its peptide inhibitor pkalin-2
Descriptor: CYS-PRO-LYS-ARG-PHE-M70-ALA-LEU-PHE-CYS, Plasma kallikrein light chain, SULFATE ION, ...
Authors:Xu, M, Jiang, L, Xu, P, Luo, Z, Andreasen, P, Huang, M.
Deposit date:2015-12-09
Release date:2016-12-14
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:The crystal structure of human Plasma Kallikrein in complex with its peptide inhibitor pkalin-2
To Be Published
8G1V
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BU of 8g1v by Molmil
Crystal Structure Matriptase (C731S) in Complex with Inhibitor MM1132-2
Descriptor: CHLORIDE ION, GLYCEROL, N~2~-{[3-(acetamidomethyl)phenyl]acetyl}-N-[(2S)-1-(1,3-benzothiazol-2-yl)-5-carbamimidamido-1,1-dihydroxypentan-2-yl]-L-leucinamide, ...
Authors:Lovell, S, Kashipathy, M.M, Battaile, K.P, Janetka, J.W.
Deposit date:2023-02-03
Release date:2024-07-10
Last modified:2024-08-14
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Use of protease substrate specificity screening in the rational design of selective protease inhibitors with unnatural amino acids: Application to HGFA, matriptase, and hepsin.
Protein Sci., 33, 2024
4XDE
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BU of 4xde by Molmil
Coagulation Factor XII protease domain crystal structure
Descriptor: CITRATE ANION, Coagulation factor XII, ISOPROPYL ALCOHOL
Authors:Pathak, M, Wilmann, P, Awford, J, Li, C, Fisher, P.M, Dreveny, I, Dekker, L.V, Emsley, J.
Deposit date:2014-12-19
Release date:2015-02-04
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Coagulation factor XII protease domain crystal structure.
J.Thromb.Haemost., 13, 2015
4XSK
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BU of 4xsk by Molmil
Structure of PAItrap, an uPA mutant
Descriptor: GLYCEROL, SULFATE ION, TRIETHYLENE GLYCOL, ...
Authors:Gong, L, Proulle, V, Hong, Z, Lin, Z, Liu, M, Yuan, C, Lin, L, Furie, B, Flaumenhaft, R, Andreasen, P, Furie, B, Huang, M.
Deposit date:2015-01-22
Release date:2016-02-03
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of PAItrap, an uPA mutant
To Be Published
4Y8X
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BU of 4y8x by Molmil
Factor XIa in complex with the inhibitor methyl (4-{4-chloro-2-[(1S)-1-({(2E)-3-[5-chloro-2-(1H-tetrazol-1-yl)phenyl]prop-2-enoyl}amino)-2-phenylethyl]-1H-imidazol-5-yl}phenyl)carbamate
Descriptor: 1,2-ETHANEDIOL, Coagulation factor XIa, SULFATE ION, ...
Authors:Sheriff, S.
Deposit date:2015-02-16
Release date:2015-05-27
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery of a Potent Parenterally Administered Factor XIa Inhibitor with Hydroxyquinolin-2(1H)-one as the P2' Moiety.
ACS Med Chem Lett, 6, 2015
8LPR
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BU of 8lpr by Molmil
STRUCTURAL BASIS FOR BROAD SPECIFICITY IN ALPHA-LYTIC PROTEASE MUTANTS
Descriptor: ALPHA-LYTIC PROTEASE, METHOXYSUCCINYL-ALA-ALA-PRO-PHENYLALANINE BORONIC ACID INHIBITOR, SULFATE ION
Authors:Fujishige, A, Bone, R, Agard, D.A.
Deposit date:1991-08-05
Release date:1993-01-15
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural basis for broad specificity in alpha-lytic protease mutants.
Biochemistry, 30, 1991
8KDU
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BU of 8kdu by Molmil
Crystal structure of trypsin with its substrate
Descriptor: (2~{R})-2-benzamido-5-carbamimidamido-pentanoic acid, ARGININE, CALCIUM ION, ...
Authors:Akbar, Z, Ahmad, M.S.
Deposit date:2023-08-10
Release date:2024-08-14
Last modified:2024-09-18
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the Michaelis complex of trypsin with N-alpha-benzoyl-l-arginine ethyl ester
J Chin Chem Soc, n/a, 2024
8R8D
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BU of 8r8d by Molmil
Cryo-EM structure of coagulation factor beta-XIIa in complex with the garadacimab Fab fragment (symmetric dimer)
Descriptor: Coagulation factor XII, Garadacimab heavy chain variable region, Garadacimab light chain variable region, ...
Authors:Drulyte, I.
Deposit date:2023-11-29
Release date:2023-12-13
Last modified:2024-09-04
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structural basis for the inhibition of beta FXIIa by garadacimab.
Structure, 2024
5WXF
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BU of 5wxf by Molmil
Crystal structure of uPA in complex with upain-2-2
Descriptor: SULFATE ION, Urokinase-type plasminogen activator chain B, upain-2-2 peptide
Authors:Jiang, L, Huang, M.
Deposit date:2017-01-07
Release date:2018-07-11
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Cleavage of peptidic inhibitors by target protease is caused by peptide conformational transition.
Biochim. Biophys. Acta, 1862, 2018

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