8R8D
Cryo-EM structure of coagulation factor beta-XIIa in complex with the garadacimab Fab fragment (symmetric dimer)
Summary for 8R8D
Entry DOI | 10.2210/pdb8r8d/pdb |
EMDB information | 18999 |
Descriptor | Coagulation factor XII, Garadacimab heavy chain variable region, Garadacimab light chain variable region, ... (5 entities in total) |
Functional Keywords | complex, coagulation, trypsin-like serine protease, hereditary angioedema (hae), blood clotting |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 6 |
Total formula weight | 150954.34 |
Authors | |
Primary citation | Drulyte, I.,Ghai, R.,Ow, S.Y.,Kapp, E.A.,Quek, A.J.,Panousis, C.,Wilson, M.J.,Nash, A.D.,Pelzing, M. Structural basis for inhibition of beta-FXIIa by garadacimab To Be Published, |
Experimental method | ELECTRON MICROSCOPY (2.6 Å) |
Structure validation
Download full validation report