8R8D
Cryo-EM structure of coagulation factor beta-XIIa in complex with the garadacimab Fab fragment (symmetric dimer)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | B, A | Coagulation factor XII | polymer | 247 | 26537.8 | 2 | UniProt (P00748) Pfam (PF00089) In PDB | Homo sapiens (human) | |
2 | E, H | Garadacimab heavy chain variable region | polymer | 234 | 25120.3 | 2 | Homo sapiens | ||
3 | I, L | Garadacimab light chain variable region | polymer | 215 | 22762.2 | 2 | Homo sapiens | ||
4 | C, D | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1057.0 | 2 | In PDB GlyTouCan (G82348BZ) | |||
5 | water | water | 18.0 | 18 | Chemie (HOH) |
Sequence modifications
B, A: 16 - 244 (UniProt: P00748)
PDB | External Database | Details |
---|---|---|
Ser 122 | Cys 486 | conflict |
Glu 245 | - | expression tag |
Pro 246 | - | expression tag |
Glu 247 | - | expression tag |
Ala 248 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 148840.4 | |
Branched | Number of molecules | 2 |
Total formula weight | 2113.9 | |
All* | Total formula weight | 150954.3 |