8R8D
Cryo-EM structure of coagulation factor beta-XIIa in complex with the garadacimab Fab fragment (symmetric dimer)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, F (B, A) | Coagulation factor XII | polymer | 247 | 26537.8 | 2 | UniProt (P00748) Pfam (PF00089) | Homo sapiens (human) | |
| 2 | B, D (E, H) | Garadacimab heavy chain variable region | polymer | 234 | 25120.3 | 2 | Homo sapiens | ||
| 3 | C, E (I, L) | Garadacimab light chain variable region | polymer | 215 | 22762.2 | 2 | Homo sapiens | ||
| 4 | G, H (C, D) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1057.0 | 2 | In PDB GlyTouCan (G82348BZ) | |||
| 5 | I, J, K, L, M... (B, E, I, H, L...) | water | water | 18.0 | 18 | Chemie (HOH) |
Sequence modifications
B, A: 16 - 244 (UniProt: P00748)
| PDB | External Database | Details |
|---|---|---|
| Ser 122 | Cys 486 | conflict |
| Glu 245 | - | expression tag |
| Pro 246 | - | expression tag |
| Glu 247 | - | expression tag |
| Ala 248 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 148840.4 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 2113.9 | |
| All* | Total formula weight | 150954.3 |
