8G1V

Crystal Structure Matriptase (C731S) in Complex with Inhibitor MM1132-2

Summary for 8G1V

• Entry DOI: 10.2210/pdb8g1v/pdb
• Descriptor: Suppressor of tumorigenicity 14 protein, SULFATE ION, CHLORIDE ION, ... (6 entities in total)
• Functional Keywords: matriptase, inhibitor complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 27805.15

Authors

Lovell, S.,Kashipathy, M.M.,Battaile, K.P.,Janetka, J.W. (deposition date: 2023-02-03, release date: 2024-07-10)

• Primary citation: Lovell, S.,Janetka, J.W.; Use of protease substrate specificity screening in the rational design of selective protease inhibitors with unnatural amino acids: Application to HGFA, matriptase and hepsin; Protein Sci., 2024

Experimental method

X-RAY DIFFRACTION (1.35 Å)