8G1V
Crystal Structure Matriptase (C731S) in Complex with Inhibitor MM1132-2
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Suppressor of tumorigenicity 14 protein | polymer | 241 | 26447.7 | 1 | UniProt (Q9Y5Y6) Pfam (PF00089) | Homo sapiens (human) | Matriptase,Membrane-type serine protease 1,MT-SP1,Prostamin,Serine protease 14,Serine protease TADG-15,Tumor-associated differentially-expressed gene 15 protein |
| 2 | B, C, D, E (A) | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
| 3 | F, G, H, I, J (A) | CHLORIDE ION | non-polymer | 35.5 | 5 | Chemie (CL) | |||
| 4 | K, L (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | M (A) | N~2~-{[3-(acetamidomethyl)phenyl]acetyl}-N-[(2S)-1-(1,3-benzothiazol-2-yl)-5-carbamimidamido-1,1-dihydroxypentan-2-yl]-L-leucinamide | non-polymer | 611.8 | 1 | Chemie (YIL) | |||
| 6 | N (A) | water | water | 18.0 | 329 | Chemie (HOH) |
Sequence modifications
A: 615 - 855 (UniProt: Q9Y5Y6)
| PDB | External Database | Details |
|---|---|---|
| Ser 731 | Cys 731 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 26447.7 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1357.5 | |
| All* | Total formula weight | 27805.1 |
