6VVU

Anti-Tryptase fab E104.v1 bound to tryptase

Summary for 6VVU

Entry DOI	10.2210/pdb6vvu/pdb
Descriptor	Tryptase alpha/beta-1, Fab E104.v1 heavy chain, Fab E104.v1 light chain, ... (6 entities in total)
Functional Keywords	fab, inhibitor, tryptase, immune system, hydrolase-immune system complex, hydrolase/immune system
Biological source	Homo sapiens (Human) More
Total number of polymer chains	12
Total formula weight	315233.71
Authors	Ultsch, M.,Koerber, J.T. (deposition date: 2020-02-18, release date: 2020-12-30, Last modification date: 2023-10-11)
Primary citation	Maun, H.R.,Vij, R.,Walters, B.T.,Morando, A.,Jackman, J.K.,Wu, P.,Estevez, A.,Chen, X.,Franke, Y.,Lipari, M.T.,Dennis, M.S.,Kirchhofer, D.,Ciferri, C.,Loyet, K.M.,Yi, T.,Eigenbrot, C.,Lazarus, R.A.,Koerber, J.T. Bivalent antibody pliers inhibit beta-tryptase by an allosteric mechanism dependent on the IgG hinge. Nat Commun, 11:6435-6435, 2020 Cited by PubMed: 33353951 DOI: 10.1038/s41467-020-20143-x PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation