6VVU

Anti-Tryptase fab E104.v1 bound to tryptase

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis
B	0004252	molecular_function	serine-type endopeptidase activity
B	0006508	biological_process	proteolysis
C	0004252	molecular_function	serine-type endopeptidase activity
C	0006508	biological_process	proteolysis
D	0004252	molecular_function	serine-type endopeptidase activity
D	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue CA A 301

Chain	Residue
A	ASN146
A	ASP147
A	0GJ302

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site_id	AC2
Number of Residues	14
Details	binding site for residue 0GJ A 302

Chain	Residue
A	GLY193
A	SER195
A	SER214
A	TRP215
A	GLY216
A	GLY219
A	GLY226
A	CA301
A	HIS57
A	GLN98
A	ASP189
A	SER190
A	CYS191
A	GLN192

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site_id	AC3
Number of Residues	2
Details	binding site for residue CA B 301

Chain	Residue
B	ASP147
B	0GJ302

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site_id	AC4
Number of Residues	14
Details	binding site for residue 0GJ B 302

Chain	Residue
B	HIS57
B	GLN98
B	ASP189
B	SER190
B	CYS191
B	GLN192
B	GLY193
B	SER195
B	SER214
B	TRP215
B	GLY216
B	GLY219
B	GLY226
B	CA301

---

site_id	AC5
Number of Residues	3
Details	binding site for residue CA D 301

Chain	Residue
D	ASN146
D	ASP147
D	0GJ302

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site_id	AC6
Number of Residues	14
Details	binding site for residue 0GJ D 302

Chain	Residue
D	HIS57
D	GLN98
D	ASP189
D	SER190
D	CYS191
D	GLN192
D	GLY193
D	SER195
D	SER214
D	TRP215
D	GLY216
D	GLY219
D	GLY226
D	CA301

---

site_id	AC7
Number of Residues	19
Details	binding site for Di-peptide 0GJ C 301 and HIS C 57

Chain	Residue
C	ALA55
C	ALA56
C	CYS58
C	VAL59
C	GLY60
C	PHE94
C	GLN98
C	ASP102
C	ASP189
C	SER190
C	CYS191
C	GLN192
C	GLY193
C	SER195
C	SER214
C	TRP215
C	GLY216
C	GLY219
C	GLY226

---

site_id	AC8
Number of Residues	19
Details	binding site for Di-peptide 0GJ C 301 and SER C 195

Chain	Residue
C	CYS42
C	GLY43
C	HIS57
C	CYS58
C	GLN98
C	ASP189
C	SER190
C	CYS191
C	GLN192
C	GLY193
C	ASP194
C	GLY196
C	GLY197
C	VAL213
C	SER214
C	TRP215
C	GLY216
C	GLY219
C	GLY226

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Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
A	LEU53-CYS58

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site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPLV

Chain	Residue	Details
A	ASP189-VAL200

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site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
F	TYR192-HIS198
E	TYR194-HIS200

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	ACT_SITE: Charge relay system

Chain	Residue	Details
A	HIS57
C	HIS57
C	ASP102
C	SER195
A	ASP102
A	SER195
B	HIS57
B	ASP102
B	SER195
D	HIS57
D	ASP102
D	SER195

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site_id	SWS_FT_FI2
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASN113
B	ASN113
D	ASN113
C	ASN113

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site_id	SWS_FT_FI3
Number of Residues	4
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218

Chain	Residue	Details
A	ASN204
B	ASN204
D	ASN204
C	ASN204

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