5FAH

KALLIKREIN-7 IN COMPLEX WITH COMPOUND1

Summary for 5FAH

Entry DOI	10.2210/pdb5fah/pdb
Descriptor	Kallikrein-7, ACETATE ION, (2~{S})-~{N}2-[2-(4-methoxyphenyl)ethyl]-~{N}1-(naphthalen-1-ylmethyl)pyrrolidine-1,2-dicarboxamide, ... (4 entities in total)
Functional Keywords	hydrolase
Biological source	Homo sapiens (Human)
Cellular location	Secreted : P49862
Total number of polymer chains	1
Total formula weight	24965.75
Authors	Ostermann, N.,Zink, F. (deposition date: 2015-12-11, release date: 2016-10-26, Last modification date: 2024-01-10)
Primary citation	Maibaum, J.,Liao, S.M.,Vulpetti, A.,Ostermann, N.,Randl, S.,Rudisser, S.,Lorthiois, E.,Erbel, P.,Kinzel, B.,Kolb, F.A.,Barbieri, S.,Wagner, J.,Durand, C.,Fettis, K.,Dussauge, S.,Hughes, N.,Delgado, O.,Hommel, U.,Gould, T.,Mac Sweeney, A.,Gerhartz, B.,Cumin, F.,Flohr, S.,Schubart, A.,Jaffee, B.,Harrison, R.,Risitano, A.M.,Eder, J.,Anderson, K. Small-molecule factor D inhibitors targeting the alternative complement pathway. Nat.Chem.Biol., 12:1105-1110, 2016 Cited by PubMed: 27775713 DOI: 10.1038/nchembio.2208 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.1 Å)

Structure validation