8G1W

Crystal Structure Matriptase (C731S) in Complex with Inhibitor VD4162B

Summary for 8G1W

• Entry DOI: 10.2210/pdb8g1w/pdb
• Descriptor: Suppressor of tumorigenicity 14 protein, Cyclic peptide inhibitor (ACE)Y(DTR)(NLE)(THZ), Cyclic peptide inhibitor (ACE)Y(DTR)(NLE)(KCM), ... (5 entities in total)
• Functional Keywords: matriptase, inhibitor complex, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 3
• Total formula weight: 28045.06

Authors

Lovell, S.,Kashipathy, M.M.,Battaile, K.P.,Janetka, J.W. (deposition date: 2023-02-03, release date: 2024-02-07, Last modification date: 2024-04-10)

• Primary citation: Damalanka, V.C.,Banas, V.,De Bona, P.,Kashipathy, M.M.,Battaile, K.,Lovell, S.,Janetka, J.W.; Mechanism-Based Macrocyclic Inhibitors of Serine Proteases.; J.Med.Chem., 67:4833-4854, 2024; PubMed: 38477709; DOI: 10.1021/acs.jmedchem.3c02388

Experimental method

X-RAY DIFFRACTION (1.2 Å)