8G1W
Crystal Structure Matriptase (C731S) in Complex with Inhibitor VD4162B
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Suppressor of tumorigenicity 14 protein | polymer | 241 | 26447.7 | 1 | UniProt (Q9Y5Y6) Pfam (PF00089) | Homo sapiens (human) | Matriptase,Membrane-type serine protease 1,MT-SP1,Prostamin,Serine protease 14,Serine protease TADG-15,Tumor-associated differentially-expressed gene 15 protein |
| 2 | B (M) | Cyclic peptide inhibitor (ACE)Y(DTR)(NLE)(THZ) | polymer | 5 | 780.0 | 1 | synthetic construct | ||
| 3 | C (L) | Cyclic peptide inhibitor (ACE)Y(DTR)(NLE)(KCM) | polymer | 5 | 782.0 | 1 | synthetic construct | ||
| 4 | D (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | E, F, G (A, M, L) | water | water | 18.0 | 258 | Chemie (HOH) |
Sequence modifications
A: 615 - 855 (UniProt: Q9Y5Y6)
| PDB | External Database | Details |
|---|---|---|
| Ser 731 | Cys 731 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 3 |
| Total formula weight | 28009.6 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 35.5 | |
| All* | Total formula weight | 28045.1 |
