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8U4O
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BU of 8u4o by Molmil
Structure of CXCL12-bound CXCR4/Gi complex
Descriptor: C-X-C chemokine receptor type 4, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Saotome, K, McGoldrick, L.L, Franklin, M.C.
Deposit date:2023-09-11
Release date:2024-03-13
Method:ELECTRON MICROSCOPY (3.29 Å)
Cite:Structural insights into CXCR4 modulation and oligomerization
Biorxiv, 2024
8U1U
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BU of 8u1u by Molmil
Structure of a class A GPCR/agonist complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, C-C motif chemokine 1,C-C chemokine receptor type 8,EGFP fusion protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Sun, D, Johnson, M, Masureel, M.
Deposit date:2023-09-02
Release date:2023-12-20
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural basis of antibody inhibition and chemokine activation of the human CC chemokine receptor 8.
Nat Commun, 14, 2023
8K4O
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BU of 8k4o by Molmil
Cryo-EM structure of Kaposi's Sarcoma-Associated Herpesvirus-G Protein-Coupled Receptor (KSHV-GPCR)in complex with CXC chemokine CXCL1
Descriptor: G protein-coupled receptor, Growth-regulated alpha protein, Guanine nucleotide-binding protein G(I) subunit alpha-1, ...
Authors:Liu, Y.Z, Liu, A.J.
Deposit date:2023-07-20
Release date:2024-07-24
Method:ELECTRON MICROSCOPY (3.01 Å)
Cite:Cryo-EM structure of Kaposi's Sarcoma Herpesvirus GPCR (KSHV-GPCR)in complex with CXCL1
To Be Published
8K3Z
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BU of 8k3z by Molmil
Cryo-EM structure of CXCR4 in complex with CXCL12
Descriptor: C-X-C chemokine receptor type 4, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Liu, Y.Z, Liu, A.J, Liao, Q.W, Ye, R.D.
Deposit date:2023-07-17
Release date:2024-07-17
Method:ELECTRON MICROSCOPY (2.81 Å)
Cite:Cryo-EM structure of CXCR4 in complex with CXCL12
To Be Published
8K2X
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BU of 8k2x by Molmil
CXCR3-DNGi complex activated by CXCL10
Descriptor: C-X-C motif chemokine 10, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Jiao, H.Z, Hu, H.L.
Deposit date:2023-07-14
Release date:2023-11-29
Last modified:2023-12-13
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structure basis for the modulation of CXC chemokine receptor 3 by antagonist AMG487.
Cell Discov, 9, 2023
8JPS
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BU of 8jps by Molmil
Structure of Duffy Antigen Receptor for Chemokines (DARC)/ACKR1 in complex with the chemokine, CCL7 (Composite map)
Descriptor: Atypical chemokine receptor 1, C-C motif chemokine 7
Authors:Banerjee, R, Khanppnavar, B, Maharana, J, Saha, S, Korkhov, V.M, Shukla, A.K.
Deposit date:2023-06-12
Release date:2024-07-31
Last modified:2024-09-04
Method:ELECTRON MICROSCOPY (3.65 Å)
Cite:Molecular mechanism of distinct chemokine engagement and functional divergence of the human Duffy antigen receptor.
Cell, 187, 2024
8SKK
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BU of 8skk by Molmil
Crystal Structure of the Tick Evasin EVA-AAM1001(L39P) Complexed to Human Chemokine CCL17
Descriptor: C-C motif chemokine 17, Evasin P1243
Authors:Devkota, S.R, Bhusal, R.P, Aryal, P, Wilce, M.C.J, Stone, M.J.
Deposit date:2023-04-19
Release date:2023-05-03
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of the Tick Evasin EVA-AAM1001(L39P) Complexed to Human Chemokine CCL7
To be Published
8IC0
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BU of 8ic0 by Molmil
Cryo-EM structure of CXCL8 bound C-X-C chemokine receptor 1 in complex with Gi heterotrimer
Descriptor: C-X-C chemokine receptor type 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Ishimoto, N, Park, J.H, Park, S.Y.
Deposit date:2023-02-10
Release date:2023-07-19
Method:ELECTRON MICROSCOPY (3.41 Å)
Cite:Structural basis of CXC chemokine receptor 1 ligand binding and activation.
Nat Commun, 14, 2023
8FK9
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BU of 8fk9 by Molmil
Crystal Structure of the Tick Evasin EVA-ACA1001 Complexed to Human Chemokine CCL16
Descriptor: C-C motif chemokine 16, Evasin P991
Authors:Devkota, S.R, Bhusal, R.P, Aryal, P, Wilce, M.C.J, Stone, M.J.
Deposit date:2022-12-21
Release date:2024-01-17
Last modified:2024-07-31
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural basis of chemokine recognition by the class A3 tick evasin EVA-ACA1001.
Protein Sci., 33, 2024
8FK8
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BU of 8fk8 by Molmil
Crystal Structure of the Tick Evasin EVA-AAM1001(L39P) Complexed to Human Chemokine CCL7
Descriptor: C-C motif chemokine 7, Evasin P1243
Authors:Devkota, S.R, Bhusal, R.P, Aryal, P, Wilce, M.C.J, Stone, M.J.
Deposit date:2022-12-20
Release date:2023-03-29
Last modified:2023-07-26
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Engineering broad-spectrum inhibitors of inflammatory chemokines from subclass A3 tick evasins.
Nat Commun, 14, 2023
8FK6
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BU of 8fk6 by Molmil
Crystal Structure of the Tick Evasin EVA-AAM1001(Y44A) Complexed to Human Chemokine CCL7
Descriptor: C-C motif chemokine 7, Evasin P1243
Authors:Devkota, S.R, Bhusal, R.P, Aryal, P, Wilce, M.C.J, Stone, M.J.
Deposit date:2022-12-20
Release date:2023-03-29
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Engineering broad-spectrum inhibitors of inflammatory chemokines from subclass A3 tick evasins.
Nat Commun, 14, 2023
8FJ3
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BU of 8fj3 by Molmil
Crystal Structure of the Tick Evasin EVA-AAM1001 Complexed to Human Chemokine CCL7(Y13A)
Descriptor: C-C motif chemokine 7, Evasin P1243
Authors:Devkota, S.R, Bhusal, R.P, Aryal, P, Wilce, M.C.J, Stone, M.J.
Deposit date:2022-12-19
Release date:2023-03-29
Last modified:2023-07-26
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Engineering broad-spectrum inhibitors of inflammatory chemokines from subclass A3 tick evasins.
Nat Commun, 14, 2023
8FJ2
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BU of 8fj2 by Molmil
Crystal Structure of the Tick Evasin EVA-AAM1001(C8) Complexed to Human Chemokine CCL17
Descriptor: C-C motif chemokine 17, Evasin P1243
Authors:Devkota, S.R, Bhusal, R.P, Aryal, P, Wilce, M.C.J, Stone, M.J.
Deposit date:2022-12-19
Release date:2023-03-29
Last modified:2023-07-26
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Engineering broad-spectrum inhibitors of inflammatory chemokines from subclass A3 tick evasins.
Nat Commun, 14, 2023
8FJ0
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BU of 8fj0 by Molmil
Crystal Structure of the Tick Evasin EVA-AAM1001(Y44A) Complexed to Human Chemokine CCL2
Descriptor: C-C motif chemokine 2, Evasin P1243
Authors:Devkota, S.R, Bhusal, R.P, Aryal, P, Wilce, M.C.J, Stone, M.J.
Deposit date:2022-12-18
Release date:2023-03-29
Last modified:2023-07-26
Method:X-RAY DIFFRACTION (2.91 Å)
Cite:Engineering broad-spectrum inhibitors of inflammatory chemokines from subclass A3 tick evasins.
Nat Commun, 14, 2023
8HNK
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BU of 8hnk by Molmil
CXCR3-DNGi complex activated by CXCL11
Descriptor: C-X-C motif chemokine 11, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Jiao, H.Z, Hu, H.L.
Deposit date:2022-12-08
Release date:2023-11-29
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.01 Å)
Cite:Structural insights into the activation and inhibition of CXC chemokine receptor 3.
Nat.Struct.Mol.Biol., 31, 2024
7XBX
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BU of 7xbx by Molmil
Cryo-EM structure of the human chemokine receptor CX3CR1 in complex with CX3CL1 and Gi1
Descriptor: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Lu, M, Zhao, W, Han, S, Zhu, Y, Wu, B, Zhao, Q.
Deposit date:2022-03-22
Release date:2022-07-13
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Activation of the human chemokine receptor CX3CR1 regulated by cholesterol.
Sci Adv, 8, 2022
7XA3
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BU of 7xa3 by Molmil
Cryo-EM structure of the CCL2 bound CCR2-Gi complex
Descriptor: C-C motif chemokine 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Shao, Z, Tan, Y, Shen, Q, Yao, B, Hou, L, Qin, J, Xu, P, Mao, C, Chen, L, Zhang, H, Shen, D, Zhang, C, Li, W, Du, X, Li, F, Chen, Z, Jiang, Y, Xu, H.E, Ying, S, Ma, H, Zhang, Y, Shen, H.
Deposit date:2022-03-17
Release date:2022-08-24
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3.
Cell Discov, 8, 2022
7T1E
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BU of 7t1e by Molmil
Structure of monomeric and dimeric human CCL20
Descriptor: C-C motif chemokine 20, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
Authors:Peterson, F.C, Riutta, S.J, Volkman, B.F.
Deposit date:2021-12-01
Release date:2022-12-14
Last modified:2024-06-26
Method:X-RAY DIFFRACTION (1.459 Å)
Cite:The Chemokine, CCL20, and Its Receptor, CCR6, in the Pathogenesis and Treatment of Psoriasis and Psoriatic Arthritis
J Psoriasis Psoriatic Arthritis, 8, 2023
7STA
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BU of 7sta by Molmil
X-ray Crystal Structure of Truncated Human Chemokine CCL19 (7-70)
Descriptor: C-C motif chemokine 19
Authors:Lewandowski, E.M, Kroeck, K, Chen, Y.
Deposit date:2021-11-12
Release date:2022-02-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Insights into Molecular Recognition by Human Chemokine CCL19.
Biochemistry, 61, 2022
7SO0
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BU of 7so0 by Molmil
Crystal Structure of the Engineered Tick Evasin EVA-P974(F31A) Complexed to Human Chemokine CCL2
Descriptor: C-C motif chemokine 2, Evasin P974
Authors:Bhusal, R.P, Devkota, S.R, Aryal, P, Wilce, M.C.J, Stone, M.J.
Deposit date:2021-10-28
Release date:2022-03-16
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Structure-guided engineering of tick evasins for targeting chemokines in inflammatory diseases.
Proc.Natl.Acad.Sci.USA, 119, 2022
7SK4
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BU of 7sk4 by Molmil
Cryo-EM structure of ACKR3 in complex with chemokine N-terminal mutant CXCL12_LRHQ, an intracellular Fab, and an extracellular Fab
Descriptor: Atypical chemokine receptor 3, CHOLESTEROL, CID24 Fab heavy chain, ...
Authors:Yen, Y.C, Schafer, C.T, Gustavsson, M, Handel, T.M, Tesmer, J.J.G.
Deposit date:2021-10-19
Release date:2022-07-27
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias.
Sci Adv, 8, 2022
7SK6
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BU of 7sk6 by Molmil
Cryo-EM structure of human ACKR3 in complex with chemokine N-terminal mutant CXCL12_LRHQ and an intracellular Fab
Descriptor: Atypical chemokine receptor 3, CID24 Fab heavy chain, CID24 Fab light chain, ...
Authors:Yen, Y.C, Schafer, C.T, Gustavsson, M, Handel, T.M, Tesmer, J.J.G.
Deposit date:2021-10-19
Release date:2022-07-27
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias.
Sci Adv, 8, 2022
7SK3
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BU of 7sk3 by Molmil
Cryo-EM structure of ACKR3 in complex with CXCL12, an intracellular Fab, and an extracellular Fab
Descriptor: Atypical chemokine receptor 3, CHOLESTEROL, CID24 Fab heavy chain, ...
Authors:Yen, Y.C, Schafer, C.T, Gustavsson, M, Handel, T.M, Tesmer, J.J.G.
Deposit date:2021-10-19
Release date:2022-07-27
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias.
Sci Adv, 8, 2022
7SK8
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BU of 7sk8 by Molmil
Cryo-EM structure of human ACKR3 in complex with CXCL12, a small molecule partial agonist CCX662, an extracellular Fab, and an intracellular Fab
Descriptor: (1R)-4-[7-(3-carboxypropoxy)-6-methylquinolin-8-yl]-1-{[2-(4-hydroxypiperidin-1-yl)-1,3-thiazol-4-yl]methyl}-1,4-diazepan-1-ium, Atypical chemokine receptor 3, CHOLESTEROL, ...
Authors:Yen, Y.C, Schafer, C.T, Gustavsson, M, Handel, T.M, Tesmer, J.J.G.
Deposit date:2021-10-19
Release date:2022-07-27
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias.
Sci Adv, 8, 2022
7SK5
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BU of 7sk5 by Molmil
Cryo-EM structure of ACKR3 in complex with CXCL12 and an intracellular Fab
Descriptor: Anti-Fab nanobody, Atypical chemokine receptor 3, CHOLESTEROL, ...
Authors:Yen, Y.C, Schafer, C.T, Gustavsson, M, Handel, T.M, Tesmer, J.J.G.
Deposit date:2021-10-19
Release date:2022-07-27
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias.
Sci Adv, 8, 2022

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PDB entries from 2024-09-18

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