7SK8
Cryo-EM structure of human ACKR3 in complex with CXCL12, a small molecule partial agonist CCX662, an extracellular Fab, and an intracellular Fab
Summary for 7SK8
Entry DOI | 10.2210/pdb7sk8/pdb |
EMDB information | 25176 |
Descriptor | Atypical chemokine receptor 3, Stromal cell-derived factor 1, CID25 Fab light chain, ... (9 entities in total) |
Functional Keywords | atypical chemokine receptor, membrane protein, signaling protein, signaling protein-immune system complex, signaling protein/immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 6 |
Total formula weight | 154884.44 |
Authors | Yen, Y.C.,Schafer, C.T.,Gustavsson, M.,Handel, T.M.,Tesmer, J.J.G. (deposition date: 2021-10-19, release date: 2022-07-27) |
Primary citation | Yen, Y.C.,Schafer, C.T.,Gustavsson, M.,Eberle, S.A.,Dominik, P.K.,Deneka, D.,Zhang, P.,Schall, T.J.,Kossiakoff, A.A.,Tesmer, J.J.G.,Handel, T.M. Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias. Sci Adv, 8:eabn8063-eabn8063, 2022 Cited by PubMed: 35857509DOI: 10.1126/sciadv.abn8063 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.3 Å) |
Structure validation
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