7SK8

Cryo-EM structure of human ACKR3 in complex with CXCL12, a small molecule partial agonist CCX662, an extracellular Fab, and an intracellular Fab

Summary for 7SK8

• Entry DOI: 10.2210/pdb7sk8/pdb
• EMDB information: 25176
• Descriptor: Atypical chemokine receptor 3, Stromal cell-derived factor 1, CID25 Fab light chain, ... (9 entities in total)
• Functional Keywords: atypical chemokine receptor, membrane protein, signaling protein, signaling protein-immune system complex, signaling protein/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 154884.44

Authors

Yen, Y.C.,Schafer, C.T.,Gustavsson, M.,Handel, T.M.,Tesmer, J.J.G. (deposition date: 2021-10-19, release date: 2022-07-27)

• Primary citation: Yen, Y.C.,Schafer, C.T.,Gustavsson, M.,Eberle, S.A.,Dominik, P.K.,Deneka, D.,Zhang, P.,Schall, T.J.,Kossiakoff, A.A.,Tesmer, J.J.G.,Handel, T.M.; Structures of atypical chemokine receptor 3 reveal the basis for its promiscuity and signaling bias.; Sci Adv, 8:eabn8063-eabn8063, 2022; PubMed: 35857509; DOI: 10.1126/sciadv.abn8063

Experimental method

ELECTRON MICROSCOPY (3.3 Å)