8FK6

Crystal Structure of the Tick Evasin EVA-AAM1001(Y44A) Complexed to Human Chemokine CCL7

Summary for 8FK6

Entry DOI	10.2210/pdb8fk6/pdb
Descriptor	Evasin P1243, C-C motif chemokine 7 (3 entities in total)
Functional Keywords	evasin, chemokine-binding protein, ticks, cytokine
Biological source	Amblyomma americanum (Lone Star tick) More
Total number of polymer chains	2
Total formula weight	20185.03
Authors	Devkota, S.R.,Bhusal, R.P.,Aryal, P.,Wilce, M.C.J.,Stone, M.J. (deposition date: 2022-12-20, release date: 2023-03-29, Last modification date: 2023-08-02)
Primary citation	Devkota, S.R.,Aryal, P.,Pokhrel, R.,Jiao, W.,Perry, A.,Panjikar, S.,Payne, R.J.,Wilce, M.C.J.,Bhusal, R.P.,Stone, M.J. Engineering broad-spectrum inhibitors of inflammatory chemokines from subclass A3 tick evasins. Nat Commun, 14:4204-4204, 2023 Cited by PubMed: 37452046 DOI: 10.1038/s41467-023-39879-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.74 Å)

Structure validation