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1VR2
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BU of 1vr2 by Molmil
HUMAN VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 2 (KDR) KINASE DOMAIN
Descriptor: PROTEIN (VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR KINASE)
Authors:Mctigue, M, Wickersham, J, Pinko, C, Showalter, R, Parast, C, Tempczyk-Russell, A, Gehring, M, Mroczkowski, B, Kan, C, Villafranca, J, Appelt, K.
Deposit date:1998-12-03
Release date:2000-03-15
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the kinase domain of human vascular endothelial growth factor receptor 2: a key enzyme in angiogenesis.
Structure Fold.Des., 7, 1999
1U46
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Crystal Structure of the Unphosphorylated Kinase Domain of the Tyrosine Kinase ACK1
Descriptor: Activated CDC42 kinase 1, CHLORIDE ION
Authors:Lougheed, J.C, Chen, R.H, Mak, P, Stout, T.J.
Deposit date:2004-07-23
Release date:2004-08-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal Structures of the Phosphorylated and Unphosphorylated Kinase Domains of the Cdc42-associated Tyrosine Kinase ACK1.
J.Biol.Chem., 279, 2004
1U59
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BU of 1u59 by Molmil
Crystal Structure of the ZAP-70 Kinase Domain in Complex with Staurosporine
Descriptor: STAUROSPORINE, Tyrosine-protein kinase ZAP-70
Authors:Jin, L, Pluskey, S, Petrella, E.C, Cantin, S.M, Gorga, J.C, Rynkiewicz, M.J, Pandey, P, Strickler, J.E, Babine, R.E, Weaver, D.T, Seidl, K.J.
Deposit date:2004-07-27
Release date:2004-08-17
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The Three-dimensional Structure of the ZAP-70 Kinase Domain in Complex with Staurosporine: IMPLICATIONS FOR THE DESIGN OF SELECTIVE INHIBITORS
J.Biol.Chem., 279, 2004
1U54
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Crystal Structures of the Phosphorylated and Unphosphorylated Kinase Domains of the CDC42-associated Tyrosine Kinase ACK1 bound to AMP-PCP
Descriptor: Activated CDC42 kinase 1, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
Authors:Lougheed, J.C, Chen, R.H, Mak, P, Stout, T.J.
Deposit date:2004-07-26
Release date:2004-08-31
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structures of the Phosphorylated and Unphosphorylated Kinase Domains of the Cdc42-associated Tyrosine Kinase ACK1.
J.Biol.Chem., 279, 2004
1YOL
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BU of 1yol by Molmil
Crystal structure of Src kinase domain in complex with CGP77675
Descriptor: 1-{4-[4-AMINO-5-(3-METHOXYPHENYL)-7H-PYRROLO[2,3-D]PYRIMIDIN-7-YL]BENZYL}PIPERIDIN-4-OL, Proto-oncogene tyrosine-protein kinase Src
Authors:Breitenlechner, C.B, Kairies, N.A, Honold, K, Scheiblich, S, Koll, H, Greiter, E, Koch, S, Schaefer, W, Huber, R, Engh, R.A.
Deposit date:2005-01-27
Release date:2006-01-27
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of active SRC kinase domain complexes
J.Mol.Biol., 353, 2005
1YOM
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BU of 1yom by Molmil
Crystal structure of Src kinase domain in complex with Purvalanol A
Descriptor: 2-({6-[(3-CHLOROPHENYL)AMINO]-9-ISOPROPYL-9H-PURIN-2-YL}AMINO)-3-METHYLBUTAN-1-OL, Proto-oncogene tyrosine-protein kinase Src
Authors:Breitenlechner, C.B, Kairies, N.A, Honold, K, Scheiblich, S, Koll, H, Greiter, E, Koch, S, Schaefer, W, Huber, R, Engh, R.A.
Deposit date:2005-01-27
Release date:2006-01-27
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structures of active SRC kinase domain complexes
J.Mol.Biol., 353, 2005
1Y6A
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Crystal structure of VEGFR2 in complex with a 2-anilino-5-aryl-oxazole inhibitor
Descriptor: N-[5-(ETHYLSULFONYL)-2-METHOXYPHENYL]-5-[3-(2-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-AMINE, Vascular endothelial growth factor receptor 2
Authors:Harris, P.A, Cheung, M, Hunter, R.N, Brown, M.L, Veal, J.M, Nolte, R.T, Wang, L, Liu, W, Crosby, R.M, Johnson, J.H, Epperly, A.H, Kumar, R, Luttrell, D.K, Stafford, J.A.
Deposit date:2004-12-05
Release date:2005-06-07
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors.
J.Med.Chem., 48, 2005
1XBB
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BU of 1xbb by Molmil
Crystal structure of the syk tyrosine kinase domain with Gleevec
Descriptor: 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, Tyrosine-protein kinase SYK
Authors:Nienaber, V.L, Atwell, S, Adams, J.M, Badger, J, Buchanan, M.D, Feil, I.K, Froning, K.J, Gao, X, Hendle, J, Keegan, K, Leon, B.C, Muller-Deickmann, H.J, Noland, B.W, Post, K, Rajashankar, K.R, Ramos, A, Russell, M, Burley, S.K, Buchanan, S.G.
Deposit date:2004-08-30
Release date:2004-11-02
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.57 Å)
Cite:A Novel Mode of Gleevec Binding Is Revealed by the Structure of Spleen Tyrosine Kinase
J.Biol.Chem., 279, 2004
1XBC
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Crystal structure of the syk tyrosine kinase domain with Staurosporin
Descriptor: STAUROSPORINE, Tyrosine-protein kinase SYK
Authors:Badger, J, Atwell, S, Adams, J.M, Buchanan, M.D, Feil, I.K, Froning, K.J, Gao, X, Hendle, J, Keegan, K, Leon, B.C, Muller-Deickmann, H.J, Nienaber, V.L, Noland, B.W, Post, K, Rajashankar, K.R, Ramos, A, Russell, M, Burley, S.K, Buchanan, S.G.
Deposit date:2004-08-30
Release date:2004-11-02
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:A novel mode of Gleevec binding is revealed by the structure of spleen tyrosine kinase
J.Biol.Chem., 279, 2004
1T45
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STRUCTURAL BASIS FOR THE AUTOINHIBITION AND STI-571 INHIBITION OF C-KIT TYROSINE KINASE
Descriptor: Homo sapiens v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
Authors:Mol, C.D, Dougan, D.R, Schneider, T.R, Skene, R.J, Kraus, M.L, Scheibe, D.N, Snell, G.P, Zou, H, Sang, B.C, Wilson, K.P.
Deposit date:2004-04-28
Release date:2004-06-15
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural basis for the autoinhibition and STI-571 inhibition of c-Kit tyrosine kinase.
J.Biol.Chem., 279, 2004
1RJB
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Crystal Structure of FLT3
Descriptor: FL cytokine receptor
Authors:Griffith, J, Black, J, Faerman, C, Swenson, L, Wynn, M, Lu, F, Lippke, J, Saxena, K.
Deposit date:2003-11-19
Release date:2004-02-03
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The structural basis for autoinhibition of FLT3 by the juxtamembrane domain.
Mol.Cell, 13, 2004
1Y6B
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BU of 1y6b by Molmil
Crystal structure of VEGFR2 in complex with a 2-anilino-5-aryl-oxazole inhibitor
Descriptor: N-(CYCLOPROPYLMETHYL)-4-(METHYLOXY)-3-({5-[3-(3-PYRIDINYL)PHENYL]-1,3-OXAZOL-2-YL}AMINO)BENZENESULFONAMIDE, Vascular endothelial growth factor receptor 2
Authors:Harris, P.A, Cheung, M, Hunter, R.N, Brown, M.L, Veal, J.M, Nolte, R.T, Wang, L, Liu, W, Crosby, R.M, Johnson, J.H, Epperly, A.H, Kumar, R, Luttrell, D.K, Stafford, J.A.
Deposit date:2004-12-05
Release date:2005-06-07
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Discovery and evaluation of 2-anilino-5-aryloxazoles as a novel class of VEGFR2 kinase inhibitors.
J.Med.Chem., 48, 2005
1YOJ
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BU of 1yoj by Molmil
Crystal structure of Src kinase domain
Descriptor: proto-oncogene tyrosine-protein kinase SRC
Authors:Breitenlechner, C.B, Kairies, N.A, Honold, K, Scheiblich, S, Koll, H, Greiter, E, Koch, S, Schaefer, W, Huber, R, Engh, R.A.
Deposit date:2005-01-27
Release date:2006-01-27
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal structures of active SRC kinase domain complexes
J.Mol.Biol., 353, 2005
1SM2
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BU of 1sm2 by Molmil
Crystal structure of the phosphorylated Interleukin-2 tyrosine kinase catalytic domain
Descriptor: STAUROSPORINE, Tyrosine-protein kinase ITK/TSK
Authors:Brown, K, Long, J.M, Vial, S.C.M, Dedi, N, Dunster, N.J, Renwick, S.B, Tanner, A.J, Frantz, J.D, Fleming, M.A, Cheetham, G.M.T.
Deposit date:2004-03-08
Release date:2004-07-16
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of interleukin-2 tyrosine kinase and their implications for the design of selective inhibitors.
J.Biol.Chem., 279, 2004
1SNU
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BU of 1snu by Molmil
CRYSTAL STRUCTURE OF THE UNPHOSPHORYLATED INTERLEUKIN-2 TYROSINE KINASE CATALYTIC DOMAIN
Descriptor: STAUROSPORINE, Tyrosine-protein kinase ITK/TSK
Authors:Brown, K, Long, J.M, Vial, S.C, Dedi, N, Dunster, N.J, Renwick, S.B, Tanner, A.J, Frantz, J.D, Fleming, M.A, Cheetham, G.M.T.
Deposit date:2004-03-12
Release date:2004-07-20
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of interleukin-2 tyrosine kinase and their implications for the design of selective inhibitors.
J.Biol.Chem., 279, 2004
1YI6
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C-term tail segment of human tyrosine kinase (258-533)
Descriptor: Proto-oncogene tyrosine-protein kinase Src
Authors:Fleury, D, Sarubbi, E, Courjaud, A, Guitton, J.D, Ducruix, A.
Deposit date:2005-01-11
Release date:2006-05-02
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the unphosphorylated C-terminal tail segment of the SRC kinase and its role in SRC activity regulation
To be published
1YWN
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Vegfr2 in complex with a novel 4-amino-furo[2,3-d]pyrimidine
Descriptor: N-{4-[4-AMINO-6-(4-METHOXYPHENYL)FURO[2,3-D]PYRIMIDIN-5-YL]PHENYL}-N'-[2-FLUORO-5-(TRIFLUOROMETHYL)PHENYL]UREA, Vascular endothelial growth factor receptor 2
Authors:Miyazaki, Y, Matsunaga, S, Tang, J, Maeda, Y, Nakano, M, Philippe, R.J, Shibahara, M, Liu, W, Sato, H, Wang, L, Nolte, R.T.
Deposit date:2005-02-18
Release date:2005-08-23
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Novel 4-amino-furo[2,3-d]pyrimidines as Tie-2 and VEGFR2 dual inhibitors
Bioorg.Med.Chem.Lett., 15, 2005
1YVJ
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BU of 1yvj by Molmil
Crystal structure of the Jak3 kinase domain in complex with a staurosporine analogue
Descriptor: (2S,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, 1,2,3,4-TETRAHYDROGEN-STAUROSPORINE, Tyrosine-protein kinase JAK3
Authors:Boggon, T.J, Li, Y, Manley, P.W, Eck, M.J.
Deposit date:2005-02-15
Release date:2005-05-24
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog
Blood, 106, 2005
1XBA
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BU of 1xba by Molmil
Crystal structure of apo syk tyrosine kinase domain
Descriptor: Tyrosine-protein kinase SYK
Authors:Atwell, S, Adams, J.M, Badger, J, Buchanan, M.D, Feil, I.K, Froning, K.J, Gao, X, Hendle, J, Keegan, K, Leon, B.C, Muller-Deickmann, H.J, Nienaber, V.L, Noland, B.W, Post, K, Rajashankar, K.R, Ramos, A, Russell, M, Burley, S.K, Buchanan, S.G.
Deposit date:2004-08-30
Release date:2004-11-02
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:A novel mode of Gleevec binding is revealed by the structure of spleen tyrosine kinase.
J.Biol.Chem., 279, 2004
1UWH
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The complex of wild type B-RAF and BAY439006.
Descriptor: 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, B-RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE, CHLORIDE ION
Authors:Barford, D, Roe, S.M, Wan, P.T.C, Cancer Genome Project
Deposit date:2004-02-05
Release date:2004-03-19
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Mechanism of Activation of the Raf-Erk Signaling Pathway by Oncogenic Mutations of B-Raf
Cell(Cambridge,Mass.), 116, 2004
1UWJ
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The complex of mutant V599E B-RAF and BAY439006.
Descriptor: 4-{4-[({[4-CHLORO-3-(TRIFLUOROMETHYL)PHENYL]AMINO}CARBONYL)AMINO]PHENOXY}-N-METHYLPYRIDINE-2-CARBOXAMIDE, B-RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
Authors:Barford, D, Roe, S.M, Wan, P.T.C, Cancer Genome Project
Deposit date:2004-02-05
Release date:2004-03-19
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Mechanism of Activation of the Raf-Erk Signaling Pathway by Oncogenic Mutations of B-Raf
Cell(Cambridge,Mass.), 116, 2004
2DQ7
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Crystal Structure of Fyn kinase domain complexed with staurosporine
Descriptor: Proto-oncogene tyrosine-protein kinase Fyn, STAUROSPORINE
Authors:Kinoshita, T, Tada, T.
Deposit date:2006-05-23
Release date:2006-07-04
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of human Fyn kinase domain complexed with staurosporine.
Biochem.Biophys.Res.Commun., 346, 2006
2BDF
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BU of 2bdf by Molmil
Src kinase in complex with inhibitor AP23451
Descriptor: Proto-oncogene tyrosine-protein kinase Src, {[(4-{[2-(4-AMINOCYCLOHEXYL)-9-ETHYL-9H-PURIN-6-YL]AMINO}PHENYL)(HYDROXY)PHOSPHORYL]METHYL}PHOSPHONIC ACID
Authors:Dalgarno, D, Stehle, T, Schelling, P, Sawyer, T, Narula, S.
Deposit date:2005-10-20
Release date:2006-10-24
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis of Src tyrosine kinase inhibition with a new class of potent and selective trisubstituted purine-based compounds.
Chem.Biol.Drug Des., 67, 2006
2BDJ
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Src kinase in complex with inhibitor AP23464
Descriptor: 3-[2-(2-CYCLOPENTYL-6-{[4-(DIMETHYLPHOSPHORYL)PHENYL]AMINO}-9H-PURIN-9-YL)ETHYL]PHENOL, Proto-oncogene tyrosine-protein kinase Src
Authors:Dalgarno, D, Stehle, T, Schelling, P, Narula, S, Sawyer, T.
Deposit date:2005-10-20
Release date:2006-10-24
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis of Src tyrosine kinase inhibition with a new class of potent and selective trisubstituted purine-based compounds.
Chem.Biol.Drug Des., 67, 2006
2E2B
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Crystal structure of the c-Abl kinase domain in complex with INNO-406
Descriptor: N-[3-(4,5'-BIPYRIMIDIN-2-YLAMINO)-4-METHYLPHENYL]-4-{[(3S)-3-(DIMETHYLAMINO)PYRROLIDIN-1-YL]METHYL}-3-(TRIFLUOROMETHYL) BENZAMIDE, Proto-oncogene tyrosine-protein kinase ABL1
Authors:Horio, T, Hamasaki, T, Wakayama, T, Takagaki, K, Ohgi, T.
Deposit date:2006-11-10
Release date:2007-05-22
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural factors contributing to the Abl/Lyn dual inhibitory activity of 3-substituted benzamide derivatives
Bioorg.Med.Chem.Lett., 17, 2007

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