1YWN

Vegfr2 in complex with a novel 4-amino-furo[2,3-d]pyrimidine

Summary for 1YWN

Entry DOI	10.2210/pdb1ywn/pdb
Related	1vr2 1y6a 1y6b
Descriptor	Vascular endothelial growth factor receptor 2, N-{4-[4-AMINO-6-(4-METHOXYPHENYL)FURO[2,3-D]PYRIMIDIN-5-YL]PHENYL}-N'-[2-FLUORO-5-(TRIFLUOROMETHYL)PHENYL]UREA (3 entities in total)
Functional Keywords	transferase
Biological source	Homo sapiens (human)
Cellular location	Cell junction . Isoform 1: Cell membrane; Single-pass type I membrane protein. Isoform 2: Secreted . Isoform 3: Secreted: P35968
Total number of polymer chains	1
Total formula weight	36892.18
Authors	Miyazaki, Y.,Matsunaga, S.,Tang, J.,Maeda, Y.,Nakano, M.,Philippe, R.J.,Shibahara, M.,Liu, W.,Sato, H.,Wang, L.,Nolte, R.T. (deposition date: 2005-02-18, release date: 2005-08-23, Last modification date: 2023-11-15)
Primary citation	Miyazaki, Y.,Matsunaga, S.,Tang, J.,Maeda, Y.,Nakano, M.,Philippe, R.J.,Shibahara, M.,Liu, W.,Sato, H.,Wang, L.,Nolte, R.T. Novel 4-amino-furo[2,3-d]pyrimidines as Tie-2 and VEGFR2 dual inhibitors Bioorg.Med.Chem.Lett., 15:2203-2207, 2005 Cited by PubMed: 15837294 DOI: 10.1016/j.bmcl.2005.03.034 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.71 Å)

Structure validation