1YWN
Vegfr2 in complex with a novel 4-amino-furo[2,3-d]pyrimidine
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Vascular endothelial growth factor receptor 2 | polymer | 316 | 36354.7 | 1 | UniProt (P35968) Pfam (PF07714) | Homo sapiens (human) | VEGFR-2, Kinase insert domain receptor, Protein-tyrosine kinase receptor Flk-1 |
| 2 | B (A) | N-{4-[4-AMINO-6-(4-METHOXYPHENYL)FURO[2,3-D]PYRIMIDIN-5-YL]PHENYL}-N'-[2-FLUORO-5-(TRIFLUOROMETHYL)PHENYL]UREA | non-polymer | 537.5 | 1 | Chemie (LIF) | |||
| 3 | C (A) | water | water | 18.0 | 209 | Chemie (HOH) |
Sequence modifications
A: 804 - 1169 (UniProt: P35968)
| PDB | External Database | Details |
|---|---|---|
| Val 988 | Glu 990 | engineered mutation |
| Ptr 1052 | Tyr 1054 | modified residue |
| Ptr 1057 | Tyr 1059 | modified residue |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36354.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 537.5 | |
| All* | Total formula weight | 36892.2 |
