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2VJ3
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BU of 2vj3 by Molmil
Human Notch-1 EGFs 11-13
Descriptor: CALCIUM ION, CHLORIDE ION, NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1, ...
Authors:Johnson, S, Cordle, J, Tay, J.Z, Roversi, P, Lea, S.M.
Deposit date:2007-12-06
Release date:2008-07-29
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:A Conserved Face of the Jagged/Serrate Dsl Domain is Involved in Notch Trans-Activation and Cis-Inhibition.
Nat.Struct.Mol.Biol., 15, 2008
6ZS5
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BU of 6zs5 by Molmil
3.5 A cryo-EM structure of human uromodulin filament core
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Uromodulin, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Stanisich, J.J, Zyla, D, Afanasyev, P, Xu, J, Pilhofer, M, Boeringer, D, Glockshuber, R.
Deposit date:2020-07-15
Release date:2020-09-02
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:The cryo-EM structure of the human uromodulin filament core reveals a unique assembly mechanism.
Elife, 9, 2020
4XL1
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BU of 4xl1 by Molmil
Complex of Notch1 (EGF11-13) bound to Delta-like 4 (N-EGF1)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Luca, V.C, Jude, K.M, Garcia, K.C.
Deposit date:2015-01-13
Release date:2015-03-04
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural biology. Structural basis for Notch1 engagement of Delta-like 4.
Science, 347, 2015
4XLW
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BU of 4xlw by Molmil
Complex of Notch1 (EGF11-13) bound to Delta-like 4 (N-EGF2)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Delta-like protein, ...
Authors:Luca, V.C, Jude, K.M, Garcia, K.C.
Deposit date:2015-01-13
Release date:2015-03-04
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.39 Å)
Cite:Structural biology. Structural basis for Notch1 engagement of Delta-like 4.
Science, 347, 2015
2W86
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BU of 2w86 by Molmil
Crystal structure of fibrillin-1 domains cbEGF9hyb2cbEGF10, calcium saturated form
Descriptor: CALCIUM ION, FIBRILLIN-1, IODIDE ION
Authors:Jensen, S.A, Iqbal, S, Lowe, E.D, Redfield, C, Handford, P.A.
Deposit date:2009-01-09
Release date:2009-05-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure and Interdomain Interactions of a Hybrid Domain: A Disulphide-Rich Module of the Fibrillin/Ltbp Superfamily of Matrix Proteins.
Structure, 17, 2009
6ZYA
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BU of 6zya by Molmil
Extended human uromodulin filament core at 3.5 A resolution
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Uromodulin, alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Stanisich, J.J, Zyla, D, Afanasyev, P, Xu, J, Pilhofer, M, Boeringer, D, Glockshuber, R.
Deposit date:2020-07-31
Release date:2020-09-02
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:The cryo-EM structure of the human uromodulin filament core reveals a unique assembly mechanism.
Elife, 9, 2020
7DO4
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BU of 7do4 by Molmil
Crystal structure of CD97-CD55 complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:Niu, M, Song, G.
Deposit date:2020-12-11
Release date:2021-09-22
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis for CD97 recognition of the decay-accelerating factor CD55 suggests mechanosensitive activation of adhesion GPCRs.
J.Biol.Chem., 296, 2021
4CUF
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BU of 4cuf by Molmil
Human Notch1 EGF domains 11-13 mutant T466S
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
Authors:Taylor, P, Takeuchi, H, Sheppard, D, Chillakuri, C, Lea, S.M, Haltiwanger, R.S, Handford, P.A.
Deposit date:2014-03-18
Release date:2014-05-14
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Fringe-Mediated Extension of O-Linked Fucose in the Ligand-Binding Region of Notch1 Increases Binding to Mammalian Notch Ligands.
Proc.Natl.Acad.Sci.USA, 111, 2014
4D0E
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BU of 4d0e by Molmil
Human Notch1 EGF domains 11-13 mutant GlcNAc-fucose disaccharide modified at T466
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-alpha-L-fucopyranose, CALCIUM ION, NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
Authors:Taylor, P, Takeuchi, H, Sheppard, D, Chillakuri, C, Lea, S.M, Haltiwanger, R.S, Handford, P.A.
Deposit date:2014-04-25
Release date:2014-05-21
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Fringe-Mediated Extension of O-Linked Fucose in the Ligand-Binding Region of Notch1 Increases Binding to Mammalian Notch Ligands.
Proc.Natl.Acad.Sci.USA, 111, 2014
4CUD
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BU of 4cud by Molmil
Human Notch1 EGF domains 11-13 mutant fucosylated at T466
Descriptor: CALCIUM ION, NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1, alpha-L-fucopyranose
Authors:Taylor, P, Takeuchi, H, Sheppard, D, Chillakuri, C, Lea, S.M, Haltiwanger, R.S, Handford, P.A.
Deposit date:2014-03-18
Release date:2014-05-21
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Fringe-Mediated Extension of O-Linked Fucose in the Ligand-Binding Region of Notch1 Increases Binding to Mammalian Notch Ligands.
Proc.Natl.Acad.Sci.USA, 111, 2014
4D0F
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BU of 4d0f by Molmil
Human Notch1 EGF domains 11-13 mutant T466A
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
Authors:Taylor, P, Takeuchi, H, Sheppard, D, Chillakuri, C, Lea, S.M, Haltiwanger, R.S, Handford, P.A.
Deposit date:2014-04-25
Release date:2014-05-21
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Fringe-Mediated Extension of O-Linked Fucose in the Ligand-Binding Region of Notch1 Increases Binding to Mammalian Notch Ligands.
Proc.Natl.Acad.Sci.USA, 111, 2014
4CUE
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BU of 4cue by Molmil
Human Notch1 EGF domains 11-13 mutant T466V
Descriptor: CALCIUM ION, NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1
Authors:Taylor, P, Takeuchi, H, Sheppard, D, Chillakuri, C, Lea, S.M, Haltiwanger, R.S, Handford, P.A.
Deposit date:2014-03-18
Release date:2014-05-21
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3 Å)
Cite:Fringe-Mediated Extension of O-Linked Fucose in the Ligand-Binding Region of Notch1 Increases Binding to Mammalian Notch Ligands.
Proc.Natl.Acad.Sci.USA, 111, 2014
2C5D
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BU of 2c5d by Molmil
Structure of a minimal Gas6-Axl complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GROWTH-ARREST-SPECIFIC PROTEIN 6 PRECURSOR, ...
Authors:Sasaki, T, Knyazev, P.G, Clout, N.J, Cheburkin, Y, Goehring, W, Ullrich, A, Timpl, R, Hohenester, E.
Deposit date:2005-10-26
Release date:2005-12-19
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural Basis for Gas6-Axl Signalling.
Embo J., 25, 2006
5CIS
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BU of 5cis by Molmil
The CUB1-EGF-CUB2 domains of rat MBL-associated serine protease-2 (MASP-2) bound to Ca2+
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Mannan-binding lectin serine peptidase 2
Authors:Nan, R, Furze, C.M, Wright, D.W, Gor, J, Wallis, R, Perkins, S.J.
Deposit date:2015-07-13
Release date:2017-01-18
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Flexibility in Mannan-Binding Lectin-Associated Serine Proteases-1 and -2 Provides Insight on Lectin Pathway Activation.
Structure, 25, 2017
5CKM
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BU of 5ckm by Molmil
The CUB1-EGF-CUB2 domains of rat MBL-associated serine protease-2 (MASP-2) bound to Ca2+
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Mannan-binding lectin serine peptidase 2
Authors:Nan, R, Furze, C.M, Wright, D.W, Gor, J, Wallis, R, Perkins, S.J.
Deposit date:2015-07-15
Release date:2017-01-18
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.73 Å)
Cite:Flexibility in Mannan-Binding Lectin-Associated Serine Proteases-1 and -2 Provides Insight on Lectin Pathway Activation.
Structure, 25, 2017
5CKN
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BU of 5ckn by Molmil
The CUB1-EGF-CUB2 domains of rat MBL-associated serine protease-2 (MASP-2) bound to Ca2+
Descriptor: CALCIUM ION, Mannan-binding lectin serine peptidase 2
Authors:Nan, R, Furze, C.M, Wright, D.W, Gor, J, Wallis, R, Perkins, S.J.
Deposit date:2015-07-15
Release date:2017-01-18
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Flexibility in Mannan-Binding Lectin-Associated Serine Proteases-1 and -2 Provides Insight on Lectin Pathway Activation.
Structure, 25, 2017
5CKQ
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BU of 5ckq by Molmil
CUB1-EGF-CUB2 domains of rat MASP-1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Mannan-binding lectin serine protease 1, ...
Authors:Nan, R, Furze, C.M, Wright, D.W, Gor, J, Wallis, R, Perkins, S.J.
Deposit date:2015-07-15
Release date:2017-01-18
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.704 Å)
Cite:Flexibility in Mannan-Binding Lectin-Associated Serine Proteases-1 and -2 Provides Insight on Lectin Pathway Activation.
Structure, 25, 2017
5FMA
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BU of 5fma by Molmil
human Notch 1, EGF 4-7
Descriptor: 1,2-ETHANEDIOL, CALCIUM ION, CHLORIDE ION, ...
Authors:Weisshuhn, P.C, Sheppard, D, Taylor, P, Whiteman, P, Lea, S.M, Handford, P.A, Redfield, C.
Deposit date:2015-11-02
Release date:2016-04-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:Non-Linear and Flexible Regions of the Human Notch1 Extracellular Domain Revealed by High-Resolution Structural Studies.
Structure, 24, 2016
1TOZ
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BU of 1toz by Molmil
NMR structure of the human NOTCH-1 ligand binding region
Descriptor: Neurogenic locus notch homolog protein 1
Authors:Hambleton, S, Valeyev, N.Y, Muranyi, A, Knott, V, Werner, J.M, Mcmichael, A.J, Handford, P.A, Downing, A.K.
Deposit date:2004-06-15
Release date:2004-10-12
Last modified:2021-11-10
Method:SOLUTION NMR
Cite:Structural and functional properties of the human notch-1 ligand binding region
STRUCTURE, 12, 2004
1UZK
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BU of 1uzk by Molmil
Integrin binding cbEGF22-TB4-cbEGF33 fragment of human fibrillin-1, Ca bound to cbEGF23 domain only
Descriptor: CALCIUM ION, FIBRILLIN-1
Authors:Lee, S.S.J, Knott, V, Harlos, K, Handford, P.A, Stuart, D.I.
Deposit date:2004-03-13
Release date:2006-05-24
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structure of the Integrin Binding Fragment from Fibrillin-1 Gives New Insights Into Microfibril Organization
Structure, 12, 2004
1UZP
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BU of 1uzp by Molmil
Integrin binding cbEGF22-TB4-cbEGF33 fragment of human fibrillin-1, Sm bound form cbEGF23 domain only.
Descriptor: FIBRILLIN-1, SAMARIUM (III) ION
Authors:Lee, S.S.J, Knott, V, Harlos, K, Handford, P.A, Stuart, D.I.
Deposit date:2004-03-15
Release date:2004-04-08
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Structure of the Integrin Binding Fragment from Fibrillin-1 Gives New Insights Into Microfibril Organization
Structure, 12, 2004
1UZJ
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BU of 1uzj by Molmil
Integrin binding cbEGF22-TB4-cbEGF33 fragment of human fibrillin-1, holo form.
Descriptor: CALCIUM ION, FIBRILLIN-1
Authors:Lee, S.S.J, Knott, V, Harlos, K, Handford, P.A, Stuart, D.I.
Deposit date:2004-03-12
Release date:2004-04-08
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure of the Integrin Binding Fragment from Fibrillin-1 Gives New Insights Into Microfibril Organization
Structure, 12, 2004
1UZQ
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BU of 1uzq by Molmil
Integrin binding cbEGF22-TB4-cbEGF33 fragment of human fibrillin-1, apo form cbEGF23 domain only.
Descriptor: FIBRILLIN-1
Authors:Lee, S.S.J, Knott, V, Harlos, K, Handford, P.A, Stuart, D.I.
Deposit date:2004-03-15
Release date:2004-04-08
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of the Integrin Binding Fragment from Fibrillin-1 Gives New Insights Into Microfibril Organization
Structure, 12, 2004
1SZB
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BU of 1szb by Molmil
Crystal structure of the human MBL-associated protein 19 (MAp19)
Descriptor: CALCIUM ION, mannose binding lectin-associated serine protease-2 related protein, MAp19 (19kDa)
Authors:Gregory, L.A, Thielens, N.M, Arlaud, G.J, Fontecilla-Camps, J.C, Gaboriaud, C.
Deposit date:2004-04-05
Release date:2004-06-22
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The X-ray structure of human MBL-associated protein 19 (MAp19) and its interaction site with mannan-binding lectin and L-ficolin
J.Biol.Chem., 279, 2004
8JUU
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BU of 8juu by Molmil
rat megalin
Descriptor: 2-acetamido-2-deoxy-alpha-D-galactopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Goto, S, Tsutsumi, A, Lee, Y, Hosojima, M, Kabasawa, H, Komochi, K, Yun-san, L, Nagatoshi, S, Tsumoto, K, Nishizawa, T, Kikkawa, M, Saito, A.
Deposit date:2023-06-27
Release date:2024-06-19
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-EM structures elucidate the multiligand receptor nature of megalin.
Proc.Natl.Acad.Sci.USA, 121, 2024

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