2VJ3

Human Notch-1 EGFs 11-13

Summary for 2VJ3

Entry DOI	10.2210/pdb2vj3/pdb
Related	1PB5 1TOZ 1YYH 2F8X 2F8Y
Descriptor	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1, CALCIUM ION, SODIUM ION, ... (5 entities in total)
Functional Keywords	transcription, metal-binding, transmembrane, developmental protein, notch signaling pathway, differentiation, phosphorylation, egf-like domain, transcription regulation, receptor, activator, ank repeat, signalling, polymorphism, glycoprotein, extracellular, egf, notch, jagged, nucleus, calcium, membrane
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	1
Total formula weight	15134.80
Authors	Johnson, S.,Cordle, J.,Tay, J.Z.,Roversi, P.,Lea, S.M. (deposition date: 2007-12-06, release date: 2008-07-29, Last modification date: 2023-12-13)
Primary citation	Cordle, J.,Johnson, S.,Tay, J.Z.,Roversi, P.,Wilkin, M.B.,De Madrid, B.H.,Shimizu, H.,Jensen, S.,Whiteman, P.,Jin, B.,Redfield, C.,Baron, M.,Lea, S.M.,Handford, P.A. A Conserved Face of the Jagged/Serrate Dsl Domain is Involved in Notch Trans-Activation and Cis-Inhibition. Nat.Struct.Mol.Biol., 15:849-, 2008 Cited by PubMed: 18660822 DOI: 10.1038/NSMB.1457 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.6 Å)

Structure validation