4D0F

Human Notch1 EGF domains 11-13 mutant T466A

Summary for 4D0F

• Entry DOI: 10.2210/pdb4d0f/pdb
• Related: 4D0E
• Descriptor: NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1, CALCIUM ION, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: transcription, metal-binding, transmembrane, developmental, protein, notch signaling pathway, differentiation, phosphorylation, egf-like domain, regulation, receptor, activator, ank repeat, signalling, glycoprotein, extracellular, jagged, nucleus, membrane
• Biological source: HOMO SAPIENS (HUMAN)
• Cellular location: Cell membrane ; Single-pass type I membrane protein . Notch 1 intracellular domain: Nucleus : P46531
• Total number of polymer chains: 1
• Total formula weight: 15009.88

Authors

Taylor, P.,Takeuchi, H.,Sheppard, D.,Chillakuri, C.,Lea, S.M.,Haltiwanger, R.S.,Handford, P.A. (deposition date: 2014-04-25, release date: 2014-05-21, Last modification date: 2023-12-20)

• Primary citation: Taylor, P.,Takeuchi, H.,Sheppard, D.,Chillakuri, C.,Lea, S.M.,Haltiwanger, R.S.,Handford, P.A.; Fringe-Mediated Extension of O-Linked Fucose in the Ligand-Binding Region of Notch1 Increases Binding to Mammalian Notch Ligands.; Proc.Natl.Acad.Sci.USA, 111:7290-, 2014; PubMed: 24803430; DOI: 10.1073/PNAS.1319683111

Experimental method

X-RAY DIFFRACTION (2.8 Å)