4D0F

Human Notch1 EGF domains 11-13 mutant T466A

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005509	molecular_function	calcium ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 1535

Chain	Residue
A	ASP452
A	VAL453
A	GLU455
A	ASP469
A	GLN470

---

site_id	AC2
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CA A 1536

Chain	Residue
A	SER435
A	VAL413
A	GLU415
A	ASN431
A	THR432

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE CA A 1537

Chain	Residue
A	ASN490
A	THR491
A	GLU493
A	ASP507
A	LYS508
A	HOH2005

---

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE EDO A 1538

Chain	Residue
A	CYS467

---

Functional Information from PROSITE/UniProt

site_id	PS00010
Number of Residues	12
Details	ASX_HYDROXYL Aspartic acid and asparagine hydroxylation site. CiNtlgsFeCqC

Chain	Residue	Details
A	CYS429-CYS440
A	CYS467-CYS478
A	CYS505-CYS516

---

site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CqClqGytGPrC

Chain	Residue	Details
A	CYS438-CYS449
A	CYS476-CYS487
A	CYS514-CYS525

---

site_id	PS01186
Number of Residues	12
Details	EGF_2 EGF-like domain signature 2. CqClqGYtgpr....C

Chain	Residue	Details
A	CYS438-CYS449
A	CYS476-CYS487
A	CYS514-CYS525

---

site_id	PS01187
Number of Residues	27
Details	EGF_CA Calcium-binding EGF-like domain signature. DvDECslganp........Cehagk..CiNtlgsFeC

Chain	Residue	Details
A	ASP412-CYS438
A	ASP452-CYS476
A	ASN490-CYS514

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	38
Details	Domain: {"description":"EGF-like 11; calcium-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	36
Details	Domain: {"description":"EGF-like 12; calcium-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	36
Details	Domain: {"description":"EGF-like 13; calcium-binding","evidences":[{"source":"PROSITE-ProRule","id":"PRU00076","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	5
Details	Region: {"description":"Interaction with DLL4","evidences":[{"source":"UniProtKB","id":"Q07008","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q07008","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Site: {"description":"Interaction with DLL4","evidences":[{"source":"UniProtKB","id":"Q07008","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Glycosylation: {"description":"O-linked (Glc...) serine","evidences":[{"source":"PubMed","id":"30127001","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Glycosylation: {"description":"O-linked (Glc...) serine","evidences":[{"source":"UniProtKB","id":"Q07008","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	1
Details	Glycosylation: {"description":"O-linked (Fuc...) threonine","evidences":[{"source":"UniProtKB","id":"Q07008","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---