4D0E
Human Notch1 EGF domains 11-13 mutant GlcNAc-fucose disaccharide modified at T466
Summary for 4D0E
Entry DOI | 10.2210/pdb4d0e/pdb |
Related | 4D0F |
Descriptor | NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-alpha-L-fucopyranose, CALCIUM ION, ... (4 entities in total) |
Functional Keywords | transcription, metal-binding, transmembrane, developmental, notch signaling pathway, differentiation, phosphorylation, egf-like domain, regulation, receptor, activator, ank repeat, signalling, glycoprotein, extracellular, jagged, nucleus, membrane |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 1 |
Total formula weight | 15385.26 |
Authors | Taylor, P.,Takeuchi, H.,Sheppard, D.,Chillakuri, C.,Lea, S.M.,Haltiwanger, R.S.,Handford, P.A. (deposition date: 2014-04-25, release date: 2014-05-21, Last modification date: 2023-12-20) |
Primary citation | Taylor, P.,Takeuchi, H.,Sheppard, D.,Chillakuri, C.,Lea, S.M.,Haltiwanger, R.S.,Handford, P.A. Fringe-Mediated Extension of O-Linked Fucose in the Ligand-Binding Region of Notch1 Increases Binding to Mammalian Notch Ligands. Proc.Natl.Acad.Sci.USA, 111:7290-, 2014 Cited by PubMed: 24803430DOI: 10.1073/PNAS.1319683111 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.61 Å) |
Structure validation
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