4CUF

Human Notch1 EGF domains 11-13 mutant T466S

Summary for 4CUF

Entry DOI	10.2210/pdb4cuf/pdb
Related	4CUD 4CUE
Descriptor	NEUROGENIC LOCUS NOTCH HOMOLOG PROTEIN 1, CALCIUM ION, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	transcription, metal-binding, transmembrane, developmental, protein, notch signaling pathway, differentiation, phosphorylation, egf-like domain, regulation, receptor, activator, ank repeat, signalling, glycoprotein, extracellular, egf, jagged, nucleus, membrane
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Cell membrane ; Single-pass type I membrane protein . Notch 1 intracellular domain: Nucleus : P46531
Total number of polymer chains	1
Total formula weight	15025.88
Authors	Taylor, P.,Takeuchi, H.,Sheppard, D.,Chillakuri, C.,Lea, S.M.,Haltiwanger, R.S.,Handford, P.A. (deposition date: 2014-03-18, release date: 2014-05-14, Last modification date: 2023-12-20)
Primary citation	Taylor, P.,Takeuchi, H.,Sheppard, D.,Chillakuri, C.,Lea, S.M.,Haltiwanger, R.S.,Handford, P.A. Fringe-Mediated Extension of O-Linked Fucose in the Ligand-Binding Region of Notch1 Increases Binding to Mammalian Notch Ligands. Proc.Natl.Acad.Sci.USA, 111:7290-, 2014 Cited by PubMed: 24803430 DOI: 10.1073/PNAS.1319683111 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.29 Å)

Structure validation