6ZS5

3.5 A cryo-EM structure of human uromodulin filament core

Summary for 6ZS5

• Entry DOI: 10.2210/pdb6zs5/pdb
• EMDB information: 11388
• Descriptor: Uromodulin, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose (3 entities in total)
• Functional Keywords: uromodulin, umod, thp, immunoglobulin-like fold, tamm-horsfall protein, glycoprotein, zp module, zona pellucida, fold complementation, beta-strand complementation, cryosparc, filament, soluble adhesion antagonist, antimicrobial protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 140978.58

Authors

Stanisich, J.J.,Zyla, D.,Afanasyev, P.,Xu, J.,Pilhofer, M.,Boeringer, D.,Glockshuber, R. (deposition date: 2020-07-15, release date: 2020-09-02)

• Primary citation: Stanisich, J.J.,Zyla, D.S.,Afanasyev, P.,Xu, J.,Kipp, A.,Olinger, E.,Devuyst, O.,Pilhofer, M.,Boehringer, D.,Glockshuber, R.; The cryo-EM structure of the human uromodulin filament core reveals a unique assembly mechanism.; Elife, 9:-, 2020; PubMed: 32815518; DOI: 10.7554/eLife.60265

Experimental method

ELECTRON MICROSCOPY (3.5 Å)