NMR structure of the human NOTCH-1 ligand binding region

Summary for 1TOZ

Related1EMO 1LMJ 1HJ7
DescriptorNeurogenic locus notch homolog protein 1 (1 entity in total)
Functional Keywordsnotch, egf, calcium binding, ligand binding, module, signaling protein
Biological sourceHomo sapiens (human)
Cellular locationCell membrane; Single-pass type I membrane protein (By similarity). Notch 1 intracellular domain: Nucleus (By similarity) P46531
Total number of polymer chains1
Total molecular weight12600.01
Hambleton, S.,Valeyev, N.Y.,Muranyi, A.,Knott, V.,Werner, J.M.,Mcmichael, A.J.,Handford, P.A.,Downing, A.K. (deposition date: 2004-06-15, release date: 2004-10-12, Last modification date: 2011-07-13)
Primary citation
Hambleton, S.,Valeyev, N.V.,Muranyi, A.,Knott, V.,Werner, J.M.,McMichael, A.J.,Handford, P.A.,Downing, A.K.
Structural and functional properties of the human notch-1 ligand binding region
STRUCTURE, 12:2173-2183, 2004
PubMed: 15576031 (PDB entries with the same primary citation)
DOI: 10.1016/j.str.2004.09.012
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliers61 8.8% 37.2%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures
Download full validation reportDownload
PDB entries from 2020-09-23