1TOZ

NMR structure of the human NOTCH-1 ligand binding region

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005509	molecular_function	calcium ion binding

Functional Information from PROSITE/UniProt

site_id	PS00010
Number of Residues	12
Details	ASX_HYDROXYL Aspartic acid and asparagine hydroxylation site. CiNtlgsFeCqC

Chain	Residue	Details
A	CYS429-CYS440
A	CYS467-CYS478
A	CYS505-CYS516

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site_id	PS00022
Number of Residues	12
Details	EGF_1 EGF-like domain signature 1. CqClqGytGPrC

Chain	Residue	Details
A	CYS438-CYS449
A	CYS476-CYS487
A	CYS514-CYS525

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site_id	PS01186
Number of Residues	12
Details	EGF_2 EGF-like domain signature 2. CqClqGYtgpr....C

Chain	Residue	Details
A	CYS438-CYS449
A	CYS476-CYS487
A	CYS514-CYS525

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site_id	PS01187
Number of Residues	27
Details	EGF_CA Calcium-binding EGF-like domain signature. DvDECslganp........Cehagk..CiNtlgsFeC

Chain	Residue	Details
A	ASP412-CYS438
A	ASP452-CYS476
A	ASN490-CYS514

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	BINDING: BINDING => ECO:0000250|UniProtKB:Q07008

Chain	Residue	Details
A	THR432
A	SER435
A	ASP452
A	VAL453
A	GLU455
A	ASP469
A	GLN470
A	ASN490
A	THR491
A	GLU493
A	ASP507
A	LYS508

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Interaction with DLL4 => ECO:0000250|UniProtKB:Q07008

Chain	Residue	Details
A	ASP469

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site_id	SWS_FT_FI3
Number of Residues	1
Details	CARBOHYD: O-linked (Glc...) serine => ECO:0000269|PubMed:30127001

Chain	Residue	Details
A	SER435

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site_id	SWS_FT_FI4
Number of Residues	2
Details	CARBOHYD: O-linked (Glc...) serine => ECO:0000250|UniProtKB:Q07008

Chain	Residue	Details
A	SER458
A	SER496

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site_id	SWS_FT_FI5
Number of Residues	1
Details	CARBOHYD: O-linked (Fuc...) threonine => ECO:0000250|UniProtKB:Q07008

Chain	Residue	Details
A	THR466

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