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8WD8
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BU of 8wd8 by Molmil
Cryo-EM structure of TtdAgo-guide DNA-target DNA complex
Descriptor: Argonaute family protein, Guide DNA, MAGNESIUM ION, ...
Authors:Zhuang, L.
Deposit date:2023-09-14
Release date:2024-01-31
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Molecular mechanism for target recognition, dimerization, and activation of Pyrococcus furiosus Argonaute.
Mol.Cell, 84, 2024
2F8S
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BU of 2f8s by Molmil
Crystal structure of Aa-Ago with externally-bound siRNA
Descriptor: 5'-R(P*AP*GP*AP*CP*AP*GP*CP*AP*UP*AP*UP*AP*UP*GP*CP*UP*GP*UP*CP*UP*UP*U)-3', Argonaute protein
Authors:Yuan, Y.R, Chen, H.Y, Patel, D.J.
Deposit date:2005-12-03
Release date:2006-10-31
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3 Å)
Cite:A Potential Protein-RNA Recognition Event along the RISC-Loading Pathway from the Structure of A. aeolicus Argonaute with Externally Bound siRNA.
Structure, 14, 2006
5G5T
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BU of 5g5t by Molmil
Structure of the Argonaute protein from Methanocaldcoccus janaschii in complex with guide DNA
Descriptor: ARGONAUTE, GUIDE DNA, MAGNESIUM ION, ...
Authors:Schneider, S, Oellig, C.A, Keegan, R, Grohmann, D, Zander, A, Willkomm, S.
Deposit date:2016-06-03
Release date:2017-02-08
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structural and mechanistic insights into an archaeal DNA-guided Argonaute protein.
Nat Microbiol, 2, 2017
5G5S
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BU of 5g5s by Molmil
Structure of the Argonaute protein from Methanocaldcoccus janaschii
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ARGONAUTE, MAGNESIUM ION
Authors:Schneider, S, Oellig, C.A, Keegan, R, Grohmann, D, Zander, A, Willkomm, S.
Deposit date:2016-06-03
Release date:2017-02-08
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:Structural and mechanistic insights into an archaeal DNA-guided Argonaute protein.
Nat Microbiol, 2, 2017
8JPX
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BU of 8jpx by Molmil
Cryo-EM structure of PfAgo-guide DNA-target DNA complex
Descriptor: Excess DNA, Guide DNA, MAGNESIUM ION, ...
Authors:Zhuang, L.
Deposit date:2023-06-13
Release date:2024-01-31
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Molecular mechanism for target recognition, dimerization, and activation of Pyrococcus furiosus Argonaute.
Mol.Cell, 84, 2024
8JSI
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BU of 8jsi by Molmil
Cryo-EM structure of a DNA-protein complex
Descriptor: Argonaute family protein, DNA (5'-D(P*AP*CP*AP*AP*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*C)-3'), DNA (5'-D(P*GP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*T)-3'), ...
Authors:Li, Z.
Deposit date:2023-06-20
Release date:2024-06-26
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Cryo-EM structure of a DNA-protein complex
To Be Published
1Z26
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BU of 1z26 by Molmil
Structure of Pyrococcus furiosus Argonaute with bound tungstate
Descriptor: Argonaute, TUNGSTATE(VI)ION
Authors:Rivas, F.V, Tolia, N.H, Song, J.J, Aragon, J.P, Liu, J, Hannon, G.J, Joshua-Tor, L.
Deposit date:2005-03-07
Release date:2005-04-05
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Purified Argonaute2 and an siRNA form recombinant human RISC.
Nat.Struct.Mol.Biol., 12, 2005
1Z25
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BU of 1z25 by Molmil
Structure of P.furiosus Argonaute with bound Mn2+
Descriptor: Argonaute, MANGANESE (II) ION
Authors:Rivas, F.V, Tolia, N.H, Song, J.J, Aragon, J.P, Liu, J, Hannon, G.J, Joshua-Tor, L.
Deposit date:2005-03-07
Release date:2005-04-05
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Purified Argonaute2 and an siRNA form recombinant human RISC.
Nat.Struct.Mol.Biol., 12, 2005
1YVU
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BU of 1yvu by Molmil
Crystal structure of A. aeolicus Argonaute
Descriptor: CALCIUM ION, hypothetical protein aq_1447
Authors:Yuan, Y.R, Pei, Y, Ma, J.B, Kuryavyi, V, Zhadina, M, Meister, G, Chen, H.Y, Dauter, Z, Tuschl, T, Patel, D.J.
Deposit date:2005-02-16
Release date:2005-08-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of A. aeolicus Argonaute provides unique perspectives into the mechanism of guide strand-mediated mRNA cleavage
Mol.Cell, 19, 2005
5T7B
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BU of 5t7b by Molmil
Argonaute-2 - 5'-(E)-vinylphosphonate 2'-O-methyl-uridine modified mrTTR guide RNA complex
Descriptor: PHENOL, Protein argonaute-2, RNA (UVP)UAUAGAGCAAGAACACUGUU
Authors:Elkayam, E, Joshua-Tor, L.
Deposit date:2016-09-02
Release date:2016-12-14
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.529 Å)
Cite:Protein structure
To Be Published
4W5Q
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BU of 4w5q by Molmil
The Crystal Structure of Human Argonaute2 Bound to a Guide and Target RNA Containing Seed Pairing from 2-8
Descriptor: MAGNESIUM ION, PHENOL, Protein argonaute-2, ...
Authors:Schirle, N.T, MacRae, I.J.
Deposit date:2014-08-18
Release date:2014-11-12
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.101 Å)
Cite:Gene regulation. Structural basis for microRNA targeting.
Science, 346, 2014
4W5R
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BU of 4w5r by Molmil
The Crystal Structure of Human Argonaute2 Bound to a Guide and Target RNA Containing Seed Pairing from 2-8 (Long Target)
Descriptor: ISOPROPYL ALCOHOL, MAGNESIUM ION, PHENOL, ...
Authors:Schirle, N.T, MacRae, I.J.
Deposit date:2014-08-18
Release date:2014-11-12
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Gene regulation. Structural basis for microRNA targeting.
Science, 346, 2014
6NIT
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BU of 6nit by Molmil
Human Argonaute2-miR-122 bound to a target RNA with four central mismatches (bu4)
Descriptor: Protein argonaute-2, RNA (5'-R(P*AP*AP*CP*AP*CP*CP*AP*UP*CP*CP*AP*AP*CP*AP*CP*UP*CP*CP*AP*AP*A)-3'), RNA (5'-R(P*UP*GP*GP*AP*GP*UP*GP*UP*GP*AP*CP*AP*AP*UP*GP*GP*UP*GP*UP*UP*U)-3')
Authors:Sheu-Gruttadauria, J, MacRae, I.J.
Deposit date:2018-12-31
Release date:2019-08-07
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Structural Basis for Target-Directed MicroRNA Degradation.
Mol.Cell, 75, 2019
8D6J
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BU of 8d6j by Molmil
Human Ago2 bound to miR122(21nt) with PIWI loop swapped to AtAgo10 sequence
Descriptor: MAGNESIUM ION, Protein argonaute-2, RNA (5'-R(P*UP*GP*GP*AP*GP*UP*GP*UP*GP*AP*CP*AP*AP*UP*GP*GP*UP*GP*UP*UP*U)-3')
Authors:Xiao, Y, MacRae, I.
Deposit date:2022-06-06
Release date:2023-05-03
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A tiny loop in the Argonaute PIWI domain tunes small RNA seed strength.
Embo Rep., 24, 2023
8D71
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BU of 8d71 by Molmil
Human Ago2 bound to miR122(21nt)
Descriptor: MAGNESIUM ION, Protein argonaute-2, miR-122-21nt
Authors:Xiao, Y, MacRae, I.
Deposit date:2022-06-07
Release date:2023-05-03
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A tiny loop in the Argonaute PIWI domain tunes small RNA seed strength.
Embo Rep., 24, 2023
6OON
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BU of 6oon by Molmil
Human Argonaute4 bound to guide RNA
Descriptor: Protein argonaute-4, RNA (5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*AP*UP*U)-3')
Authors:Park, M.S, Brackbill, J.A, Nakanishi, K.
Deposit date:2019-04-23
Release date:2019-07-31
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Multidomain Convergence of Argonaute during RISC Assembly Correlates with the Formation of Internal Water Clusters.
Mol.Cell, 75, 2019
4F1N
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BU of 4f1n by Molmil
Crystal structure of Kluyveromyces polysporus Argonaute with a guide RNA
Descriptor: KpAGO, RNA 5'-R(P*UP*AP*AP*AP*AP*AP*AP*AP*A)-3'
Authors:Nakanishi, K, Weinberg, D.E, Bartel, D.P, Patel, D.J.
Deposit date:2012-05-07
Release date:2012-06-13
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (3.187 Å)
Cite:Structure of yeast Argonaute with guide RNA.
Nature, 486, 2012
4F3T
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BU of 4f3t by Molmil
Human Argonaute-2 - miR-20a complex
Descriptor: PHENOL, Protein argonaute-2, RNA (5'-R(P*UP*AP*AP*AP*GP*UP*GP*CP*UP*UP*AP*UP*AP*GP*UP*G*CP*AP*GP*G)-3')
Authors:Elkayam, E, Kuhn, C.-D, Tocilj, A, Joshua-Tor, L.
Deposit date:2012-05-09
Release date:2012-05-30
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:The Structure of Human Argonaute-2 in Complex with miR-20a.
Cell(Cambridge,Mass.), 150, 2012
4OLB
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BU of 4olb by Molmil
Crystal Structure of Human Argonaute2 Bound to Tryptophan
Descriptor: 5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*U)-3', Protein argonaute-2, TRYPTOPHAN
Authors:Schirle, N.T, MacRae, I.J.
Deposit date:2014-01-23
Release date:2014-02-05
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.899 Å)
Cite:The crystal structure of human Argonaute2.
Science, 336, 2012
4OLA
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BU of 4ola by Molmil
Crystal Structure of Human Argonaute2
Descriptor: 5'-R(P*AP*AP*AP*AP*AP*AP*AP*AP*AP*U)-3', ISOPROPYL ALCOHOL, PHENOL, ...
Authors:Schirle, N.T, MacRae, I.J.
Deposit date:2014-01-23
Release date:2014-02-05
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The crystal structure of human Argonaute2.
Science, 336, 2012
4W5T
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BU of 4w5t by Molmil
The Crystal Structure of Human Argonaute2 Bound to a Guide and Target RNA Containing Seed Pairing from 2-7
Descriptor: MAGNESIUM ION, PHENOL, Protein argonaute-2, ...
Authors:Schirle, N.T, MacRae, I.J.
Deposit date:2014-08-18
Release date:2014-11-12
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Gene regulation. Structural basis for microRNA targeting.
Science, 346, 2014
4W5N
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BU of 4w5n by Molmil
The Crystal Structure of Human Argonaute2 Bound to a Defined Guide RNA
Descriptor: MAGNESIUM ION, PHENOL, Protein argonaute-2, ...
Authors:Schirle, N.T, Sheu-Gruttadauria, J, MacRae, I.J.
Deposit date:2014-08-18
Release date:2014-11-12
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Gene regulation. Structural basis for microRNA targeting.
Science, 346, 2014
5KI6
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BU of 5ki6 by Molmil
Human Argonaute-2 bound to a guide RNA with a nucleobase modification at position 1
Descriptor: PHENOL, Protein argonaute-2, miR-122
Authors:Schirle, N.T, MacRae, I.J.
Deposit date:2016-06-16
Release date:2016-07-20
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.153 Å)
Cite:Structure-Guided Control of siRNA Off-Target Effects.
J.Am.Chem.Soc., 138, 2016
4W5O
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BU of 4w5o by Molmil
The Crystal Structure of Human Argonaute2 Bound to a Guide and Target RNA Containing Seed Pairing from 2-9
Descriptor: ISOPROPYL ALCOHOL, MAGNESIUM ION, PHENOL, ...
Authors:Schirle, N.T, MacRae, I.J.
Deposit date:2014-08-18
Release date:2014-11-12
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.802 Å)
Cite:Gene regulation. Structural basis for microRNA targeting.
Science, 346, 2014
7KX7
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BU of 7kx7 by Molmil
Cryo-EM structure of Ephydatia fluviatilis PiwiA-piRNA complex
Descriptor: MAGNESIUM ION, Piwi-A, RNA (5'-R(P*UP*CP*UP*CP*AP*GP*(OMC))-3')
Authors:Anzelon, T.A, Chowdhury, S, Lander, G.C, MacRae, I.J.
Deposit date:2020-12-03
Release date:2021-07-14
Last modified:2024-05-29
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural basis for piRNA targeting.
Nature, 597, 2021

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PDB entries from 2024-09-18

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