4W5N

The Crystal Structure of Human Argonaute2 Bound to a Defined Guide RNA

Summary for 4W5N

• Entry DOI: 10.2210/pdb4w5n/pdb
• Related: 4W5O 4W5Q 4W5R 4W5T
• Descriptor: Protein argonaute-2, RNA (5'-R(P*UP*UP*CP*AP*CP*AP*UP*UP*CP*AP*AP*GP*UP*CP*UP*CP*UP*U)-3'), PHENOL, ... (5 entities in total)
• Functional Keywords: ago2, rnase, rnai, rna, hydrolase-rna complex, hydrolase/rna
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm, P-body : Q9UKV8
• Total number of polymer chains: 2
• Total formula weight: 104232.69

Authors

Schirle, N.T.,Sheu-Gruttadauria, J.,MacRae, I.J. (deposition date: 2014-08-18, release date: 2014-11-12, Last modification date: 2023-09-27)

• Primary citation: Schirle, N.T.,Sheu-Gruttadauria, J.,MacRae, I.J.; Gene regulation. Structural basis for microRNA targeting.; Science, 346:608-613, 2014; PubMed: 25359968; DOI: 10.1126/science.1258040

Experimental method

X-RAY DIFFRACTION (2.9 Å)