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5KI6

Human Argonaute-2 bound to a guide RNA with a nucleobase modification at position 1

Summary for 5KI6
Entry DOI10.2210/pdb5ki6/pdb
DescriptorProtein argonaute-2, miR-122, PHENOL, ... (4 entities in total)
Functional Keywordsargonaute, mirna, rnai, hydrolase-rna complex, hydrolase/rna
Biological sourceHomo sapiens (Human)
More
Total number of polymer chains2
Total formula weight104561.70
Authors
Schirle, N.T.,MacRae, I.J. (deposition date: 2016-06-16, release date: 2016-07-20, Last modification date: 2023-09-27)
Primary citationSuter, S.R.,Sheu-Gruttadauria, J.,Schirle, N.T.,Valenzuela, R.,Ball-Jones, A.A.,Onizuka, K.,MacRae, I.J.,Beal, P.A.
Structure-Guided Control of siRNA Off-Target Effects.
J.Am.Chem.Soc., 138:8667-8669, 2016
Cited by
PubMed: 27387838
DOI: 10.1021/jacs.6b06137
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.153 Å)
Structure validation

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