5KI6
Human Argonaute-2 bound to a guide RNA with a nucleobase modification at position 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Protein argonaute-2 | polymer | 859 | 97378.2 | 1 | UniProt (Q9UKV8) Pfam (PF16486) Pfam (PF08699) Pfam (PF02170) Pfam (PF16488) Pfam (PF16487) Pfam (PF02171) In PDB | Homo sapiens (Human) | hAgo2,Argonaute RISC catalytic component 2,Eukaryotic translation initiation factor 2C 2,eIF2C 2,PAZ Piwi domain protein,PPD,Protein slicer |
| 2 | B | miR-122 | polymer | 21 | 6901.2 | 1 | Homo sapiens | ||
| 3 | A | PHENOL | non-polymer | 94.1 | 3 | Chemie (IPH) | |||
| 4 | water | water | 18.0 | 105 | Chemie (HOH) |
Sequence modifications
A: 1 - 859 (UniProt: Q9UKV8)
| PDB | External Database | Details |
|---|---|---|
| Asp 387 | Ser 387 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 104279.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 282.3 | |
| All* | Total formula weight | 104561.7 |
